138964-58-6

Basic information

• Product Name: Benzoic acid, 5-chloro-2-[(phenylsulfonyl)amino]-
• CAS NO: 138964-58-6
• Molecular Formula: C13H10ClNO4S
• Molecular Weight: 311.746
• Mol File: 138964-58-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 5-chloro-2-[(phenylsulfonyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 5-chloro-2-[(phenylsulfonyl)amino]-(138964-58-6)
• EPA Substance Registry System: Benzoic acid, 5-chloro-2-[(phenylsulfonyl)amino]-(138964-58-6)

Safety Data

• Hazardous Substances Data: 138964-58-6(Hazardous Substances Data)

Upstream product

• 138964-52-0 6-Chloro-1H-quinoline-2,4-dione 
• 106-47-8 4-chloro-aniline 
• 98-09-9 benzenesulfonyl chloride 
• 5202-89-1 4-chlorobenzenesulfonyl chloride 
• 209688-07-3 methyl 5-chloro-2-[(phenylsulfonyl)amino]benzoate 
• 138964-55-3 6-chloro-1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oxime 
• 635-21-2 5-chloroanthranilic acid 
• 1677-36-7 6-chloro-4-hydroxyquinolin-2(1H)-one 

Downstream Products

• 719-59-5 5-chloro-2-aminobenzophenone 
• 474448-77-6 2-benzenesulfonylamino-5-chloro-benzoyl chloride 
• 209685-00-7 methyl 4-({5-chloro-2-[(phenylsulfonyl)amino]benzoyl}amino)benzoate 

Relevant articles and documents

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Discovery of new chemical leads for selective EP1 receptor antagonists

A series of 4-({2-[alkyl(phenylsulfonyl)amino]phenoxy}methyl)benzoic acids were identified as functional PGE2 antagonists with selectivity for the EP1 receptor subtype starting from a chemical lead 1, which was found while screening our in-house compound library. Discovery of the optimized analogs 21-23 is presented here and structure-activity relationships (SAR) are also discussed.

Synthesis of certain sulphonamides and aminopyranoquinoline derivatives from 4-hydroxyquinoline with biological interest

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