138971-33-2

Upstream product

• 67-56-1 methanol 
• 138971-30-9 Phosphoric acid diethyl ester 1-(4-trifluoromethyl-phenyl)-hex-5-enyl ester 
• 1204403-32-6 1-[4-(trifluoromethyl)phenyl]allyl isopropyl carbonate 
• 72824-04-5 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 79756-87-9 1-(prop-1-ynyl)-4-trifluoromethylbenzene 
• 36971-15-0 3-isopropyl-2-methyl-hex-5-en-3-ol 

Relevant academic research and scientific papers

Synthesis method of 1, 5-diene derivative

The invention belongs to the technical field of pharmaceutical and chemical intermediates and related chemistry, and provides a preparation method of a 1, 5-diene derivative. The method comprises thefollowing steps: taking aryl substituted propyne and allyl boron ester as reaction raw materials, adopting 2-10mol% of a palladium catalyst, adding 2mol%-20mol% of acid and 100mol%-300mol% of alcoholas additives, and performing heating and stirring in an organic solvent for a certain period of time to generate the 1, 5-diene compound. The method disclosed by the invention has the beneficial effects that the operation is simple and convenient, the condition is mild, the method is environment-friendly, the catalyst can be recycled, the possibility of industrialization is realized, and the 1, 5-diene compound is obtained at a relatively high yield; and the 1, 5-diene compound synthesized by the method can be further functionalized to obtain various compounds, and is applied to development and research of natural products, functional materials and fine chemicals.

A regioselectivity switch in Pd-catalyzed hydroallylation of alkynes

By exploiting the reactivity of a vinyl-Pd species, we control the regioselectivity in hydroallylation of alkynes under Pd-hydride catalysis. A monophosphine ligand and carboxylic acid combination promotes 1,5-dienes through a pathway involving isomerization of alkynes to allenes. In contrast, a bisphosphine ligand and copper cocatalyst favor 1,4-dienes via a mechanism that involves transmetalation. Our study highlights how to access different isomers by diverting a common organometallic intermediate.

Palladium(0) versus nickel(0) catalysis in selective functional- grouptolerant sp3-sp3 carbon-carbon bond formations

We have uncovered Pd°-catalyzed intermolecular nonsymmetrical Suzuki-Miyaura-type sp3-sp3 C-C bond formations between allyl carbonates and nontoxic allyl, allenyl, or propargyl boronates. This report represents the first use of these

Nickel-catalyzed allylation of allyl carbonates with homoallyl alcohols via retro-allylation providing 1,5-hexadienes

A highly efficient and mild method for the synthesis of 1,5-hexadienes, nickel-catalyzed reactions of Boc-protected allyl alcohols with homoallyl alcohols, has been developed. Nickel-mediated retro-allylation allows for the use of homoallyl alcohols as allylmetal equivalents in the synthesis of 1,5-hexadienes.2008 American Chemical Society.

Mechanistic pathways in phosphate ester photochemistry

Initial bond breaking processes (homolysis vs heterolysis) of phosphate ester photosolvolysis were probed by chemically trapping the reactive intermediates with a tethered 5-hexenyl group. The resulting mechanistic picture is a blend of homolytic and heterolytic pathways, where the heterolytic cleavage is dominant.