138998-63-7Relevant academic research and scientific papers
Design synthesis and antibacterial activity studies of new thiadiazoloquinolone compounds
Al-Qawasmeh, Raed A.,Abadleh, Mohammed M.,Zahra, Jalal A.,El-Abadelah, Mustafa M.,Albashiti, Rabab,Zani, Franca,Incerti, Matteo,Vicini, Paola
, p. 777 - 785 (2014)
New 9-(alkyl/aryl)-4-fluoro-6-oxo[1,2,5]thiadiazolo[3,4-h]quinoline-5-carboxylic acids and their esters were designed and synthesized. A detailed discussion of the reactions utilized in the preparation of the intermediate and target compounds is reported.
In vitro modulation of pancreatic lipase and proliferation of obesity related colorectal cancer cell line panel by novel synthetic fluoroquinolones
Alabsi, Yousef,Al-Hiari, Yusuf,Kasabri, Violet,Arabiyat, Shereen,Bashiti, Rabab,Alalawi, Sundos,Al-Shahrabi, Rula
, p. 1123 - 1134 (2019/04/05)
Ten novel fluoroquinolones (FQs) were investigated in vitro for pancreatic lipase (PL) inhibitory propensities in comparison to orlistat, the robust reference agent for potency and efficacy determinations. In comparison to the antineoplastic agent cisplat
Structure based drug design of Pim-1 kinase followed by pharmacophore guided synthesis of quinolone-based inhibitors
Swellmeen, Lubna,Shahin, Rand,Al-Hiari, Yusuf,Alamiri, Amani,Hasan, Alaa,Shaheen, Omar
, (2017/10/06)
Over expression of Human phosphatidyl inositol mannoside kinases isoform 1 (Pim-1 kinase) has been reported in several leukemia and solid tumors. Our continuous interest to reveal the secrecies of the mysterious Pim-1 kinase binding pocket has led us to e
Indolo[2,3-b]-, Indeno[1,2-b]- and Indeno[2,1-b]pyrido[2,3-f] quinoxaline-3-carboxylic acids and esters, processes for their preparation and their use as antiviral, antibiotic and antitumor agents
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Page/Page column 13; 14, (2009/12/23)
The present invention relates to novel quinoxaline derivatives represented by regioisomeric structures of quinoxalines of general formulas I and/or II, wherein the COOR1 group independently is an acid, an ester and/or a salt, Y1 and/
Synthesis and antibacterial properties of new 8-nitrofluoroquinolone derivatives
Al-Hiari, Yusuf M.,Al-Mazari, Inas Saleh,Shakya, Ashok K.,Darwish, Rula M.,Abu-Dahab, Rana
, p. 1240 - 1258 (2008/02/08)
The objective of this research was the preparation of new 8-nitrofluoroquinolone models and investigation of their antibacterial properties. The work initially involved large scale preparation of the synthon 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1
Heterocycles [h]fused onto 4-oxoquinolines. Part I. synthesis of 6-oxo-6,9-dihydro[1,2,5]oxadiazolo[3,4-h-quinoline-7-carboxylic acid N-oxide
Al-Hiari, Yusuf M.,Khanfar, Monther A.,Qaisi, Ali M.,Abu Shuheil, Mohammad Y.,El-Abadelah, Mustafa M.,Boese, Roland
, p. 1163 - 1172 (2007/10/03)
Ethyl 9-cyclopropyl-4-fluoro-6-oxo-6,9-dihydro[ 1,2,5]oxadiazolo[3,4-h]quinoline-7-carboxylate N(3)-oxide (3) is synthesized via pyrolysis of the 7-azido-8-nitroquinoline-3-carboxylate precursor (6). Acid-catalyzed hydrolysis of the product (3) afforded t
