138998-63-7Relevant articles and documents
Design synthesis and antibacterial activity studies of new thiadiazoloquinolone compounds
Al-Qawasmeh, Raed A.,Abadleh, Mohammed M.,Zahra, Jalal A.,El-Abadelah, Mustafa M.,Albashiti, Rabab,Zani, Franca,Incerti, Matteo,Vicini, Paola
, p. 777 - 785 (2014)
New 9-(alkyl/aryl)-4-fluoro-6-oxo[1,2,5]thiadiazolo[3,4-h]quinoline-5-carboxylic acids and their esters were designed and synthesized. A detailed discussion of the reactions utilized in the preparation of the intermediate and target compounds is reported.
Structure based drug design of Pim-1 kinase followed by pharmacophore guided synthesis of quinolone-based inhibitors
Swellmeen, Lubna,Shahin, Rand,Al-Hiari, Yusuf,Alamiri, Amani,Hasan, Alaa,Shaheen, Omar
, (2017/10/06)
Over expression of Human phosphatidyl inositol mannoside kinases isoform 1 (Pim-1 kinase) has been reported in several leukemia and solid tumors. Our continuous interest to reveal the secrecies of the mysterious Pim-1 kinase binding pocket has led us to e
Synthesis and antibacterial properties of new 8-nitrofluoroquinolone derivatives
Al-Hiari, Yusuf M.,Al-Mazari, Inas Saleh,Shakya, Ashok K.,Darwish, Rula M.,Abu-Dahab, Rana
, p. 1240 - 1258 (2008/02/08)
The objective of this research was the preparation of new 8-nitrofluoroquinolone models and investigation of their antibacterial properties. The work initially involved large scale preparation of the synthon 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1
