139047-55-5 Usage
Uses
Used in Pharmaceutical Industry:
2-PMDQ is used as a pharmaceutical agent for its beneficial hemodynamic effects in portal hypertensive rats. It is particularly useful in managing and treating conditions related to high blood pressure and hypertension.
Used in Cardiovascular Applications:
2-PMDQ is used as an anti-hypertensive agent to help regulate blood pressure and improve cardiovascular health. Its effects on hemodynamics make it a promising candidate for the development of treatments for various cardiovascular diseases.
Biological Activity
Very potent ligand for α 1 sites (K i for displacement of prazosin = 0.2 nM). Also binds to 5-HT 1A sites (K i = 50 nM).
Check Digit Verification of cas no
The CAS Registry Mumber 139047-55-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,0,4 and 7 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 139047-55:
(8*1)+(7*3)+(6*9)+(5*0)+(4*4)+(3*7)+(2*5)+(1*5)=135
135 % 10 = 5
So 139047-55-5 is a valid CAS Registry Number.
139047-55-5Relevant academic research and scientific papers
Studies on Quinazolines. 5. 2,3-Dihydroimidazoquinazoline Derivatives: A Novel Class of Potent and Selective α1-Adrenoceptor Antagonists and Antihypertensive Agents
Chern, Ji-Wang,Tao, Pao-Luh,Yen, Mao-Hsiung,Lu, Guan-Yu,Shiau, Chia-Yang,et al.
, p. 2196 - 2207 (2007/10/02)
A series of 2-- and 2--2,3-dihydroimidazoquinazolin-5(6H)-ones or -5(6H)-thiones, and 3--2,3-dihydroimidazoquinazol
2-substituted methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-ones (thiones), the preparation and use thereof
-
, (2008/06/13)
The present invention provides a novel series of 2-substituted methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-ones (-thiones) compounds. These compounds are found useful as an active ingredient for the prophylaxis and treatment of hypertension.
