1390656-46-8

Upstream product

• 20443-98-5 2,6-Dichlorobenzyl bromide 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 99-11-6 citrazinic acid 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 
• 1017782-79-4 tert-butyl 4-(3-methoxy-4-nitrophenyl)piperazine-1-carboxylate 
• 1246532-96-6 tert-butyl 4-(4-amino-3-methoxy-phenyl)-piperazine-1-carboxylate 
• 918898-03-0 4-amino-2,6-dichloropyridine-3-carboxamide 
• 918898-11-0 5,7-dichloropyrido[4,3-d]pyrimidin-4(3H)-one 
• 501907-61-5 tert-butyl (2,6-dichloropyridin-4-yl)carbamate 
• 929288-17-5 4-(tert-butoxycarbonylamino)-2,6-dichloronicotinic acid 

Downstream Products

• 1390656-47-9 tert-butyl 4-(4-(7-(2,6-dichlorobenzyl)-1,2,3,4-tetrahydro-4-oxopyrido[4,3-d]pyrimidin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1390655-11-4 7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-2,3-dihydropyrido[4,3-d]pyrimidin-4(1H)-one 
• 1391001-05-0 7-(2,6-dichlorobenzyl)-5-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}pyrido[4,3-d]pyrimidin-4(3H)-one 

Relevant academic research and scientific papers

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R1, R2, R3, X, Y, Z, A, B, G1, m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein R1, X, Y, Z, A, B, G1, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

BICYCLIC INHIBITORS OF ANAPHASTIC LYMPHOMA KINASE

Disclosed are compounds of formula (Ⅰ) and their pharmaceutical acceptable salts, wherein R1, R2, R3, X, Y, Z, A, B, G1, m and n are defined in the description. The compositions containing the said compounds used for inhibiting kinases such as anaphastic lymphoma kinase (ALK) and methods of treating diseases such as cancer are disclosed.

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R1, R2, R3, X, Y, Z, A, B, G1, m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.