139115-89-2

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 

Downstream Products

• 86520-52-7 2-[2-(2-azidoethoxy)ethoxy]ethanol 
• 1264718-69-5 2-(3,5-bis((E)-4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)-N-((1-(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide 
• 189808-70-6 tert-butyl 2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetate 
• 172531-36-1 tert-butyl 2-[2-(2-(2-azidoethoxy)ethoxy)ethoxy]acetate 
• 139115-92-7 tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamate 
• 6338-55-2 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol 
• 172531-37-2 11-azido-3,6,9-trioxaundecanoic acid 
• 134978-99-7 2-<2-<2-(aminoethoxy)ethoxy>ethoxy>acetic acid 
• 1432887-47-2 C₅₀H₅₂BF₂N₇O₄ 
• 1432887-39-2 C₄₁H₄₇BF₂N₆O₄ 

Relevant academic research and scientific papers

Synthesis of water soluble axially disubstituted silicon (IV) phthalocyanines with alkyne & azide functionality

Phthalocyanines (Pcs) are a class of photosensitizers (PSs) with a strong tendency to aggregate in aqueous solutions, which has a negative influence on their photosensitizing ability for photodynamic therapy. Four new axially disubstituted, non-aggregated silicon phthalocyanines (SiPcs), containing azide or alkyne functional groups have been synthesized and characterized. The method of synthesis is based on the reaction of silicon phthalocyanine dichloride with variable length poly(ethylene glycol) (PEG) chains in the presence of NaH. All synthesized dyes are highly soluble in alcohols, THF, CH2 Cl2, acetone, DMF and other common polar organic solvents, with the PEGylated silicon phthalocyanines (SiPcs) also being soluble in water. Photophysical and electrochemical properties of the dyes have been investigated. The presence of alkyne or azide groups in the phthalocyanine dyes, coupled with their high aqueous solubility, make these compounds useful as building blocks in copper catalyzed Huigsen azide-alkyne cycloaddition reactions (i.e. click chemistry).

Targeting Colorectal Cancer with Conjugates of a Glucose Transporter Inhibitor and 5-Fluorouracil

Overexpression of glucose transporters (GLUTs) in colorectal cancer cells is associated with 5-fluorouracil (1, 5-FU) resistance and poor clinical outcomes. We designed and synthesized a novel GLUT-targeting drug conjugate, triggered by glutathione in the tumor microenvironment, that releases 5-FU and GLUTs inhibitor (phlorizin (2) and phloretin (3)). Using an orthotopic colorectal cancer mice model, we showed that the conjugate exhibited better antitumor efficacy than 5-FU, with much lower exposure of 5-FU during treatment and without significant side effects. Our study establishes a GLUT-targeting theranostic incorporating a disulfide linker between the targeting module and cytotoxic payload as a potential antitumor therapy.

Sugar-decorated hydroxyapatite: An inorganic material bioactivated with carbohydrates

An efficient method for the direct and covalent decoration of granules of nanostructured apatite with a sample monosaccharide is presented; the hydroxyapatite material was directly functionalised with a short azido-containing spacer arm, to which α-propargyl glucopyranoside has been chemoselectively ligated by Huisgen-type cycloaddition. The 'glycosylated' hydroxypatite was characterised by its ability to interact with glucose recognising lectins.

ELECTROCHEMICALLY-CLEAVABLE LINKERS

This disclosure provides electrochemically-cleavable linkers with cleavage potentials that are less than the redox potential of the solvent in which the linkers are used. In some applications, the solvent may be water or an aqueous buffer solution. The linkers may be used to link a nucleotide to a bound group. The linkers include a cleavable group which may be one of a methoxybenzyl alcohol, an ester, a propargyl thioether, or a trichloroethyl ether. The linkers may be cleaved in solvent by generating an electrode potential that is less than the redox potential of the solvent. In some implementations, an electrode array may be used to generate localized electrode potentials which selectively cleave linkers bound to the activated electrode. Uses for the linkers include attachment of blocking groups to nucleotides in enzymatic oligonucleotide synthesis.

Synthesis of a series of ethylene glycol modified water-soluble tetrameric TPE-amphiphiles with pyridinium polar heads: Towards applications as light-up bioprobes in protein and DNA assay, and wash-free imaging of bacteria

Available online Development of water soluble AIE-active “light-up” bioprobes for the detection of biomacromolecules has drawn huge research interests in recent past. In this study, a series of ethylene glycol modified water soluble tetrameric tetraphenyl

Compounds Useful for Promoting Protein Degradation and Methods Using Same

The present description includes compounds that act as degraders of a target protein, wherein degradation is independent of the class of the target protein or its localization. In certain embodiments, the description includes a compound comprising a protein degradation moiety covalently bound to a linker, wherein the ClogP of the compound is equal to or higher than 1.5. The target protein contemplated within the description comprises an androgen receptor. Compounds of the present description may be used to treat disease states wherein protein degradation is a viable therapeutic approach, such as cancer or any sort of oxidative stress disease state.

SULFORAPHANE-DERIVED COMPOUNDS, PRODUCTION METHOD THEREOF AND THE MEDICAL, FOOD AND COSMETIC USE OF SAME

The present invention relates to a new series of compounds having general formula (I) and the optical isomer or enantiomer forms thereof, which belong to the family of sulforaphane derivatives. The invention also relates to the production method thereof. The invention further relates to the multiple medical (pharmaceutical, homeopathic and phytotherapeutic), food, cosmetic and dietary uses of said series of compounds, especially the use thereof in the prevention and/or treatment of diseases and any type of illness or damage associated with an oxidative process or which, although not involved in said process, are mediated by the Nrf2 transcription factor, such as, for example, cancer. The compounds can be used alone or, alternatively, encapsulated in cyclodextrins.

SULFORAPHANE-DERIVED COMPOUNDS, PRODUCTION METHOD THEREOF AND THE MEDICAL, FOOD AND COSMETIC USE OF SAME

The present invention relates to a new series of compounds having general formula (I) and the optical isomer or enantiomer forms thereof, which belong to the family of sulforaphane derivatives. The invention also relates to the production method thereof. The invention further relates to the multiple medical (pharmaceutical, homeopathic and phytotherapeutic), food, cosmetic and dietary uses of said series of compounds, especially the use thereof in the prevention and/or treatment of diseases and any type of illness or damage associated with an oxidative process or which, although not involved in said process, are mediated by the Nrf2 transcription factor, such as, for example, cancer. The compounds can be used alone or, alternatively, encapsulated in cyclodextrins.

Nanofibers and morphology shifting micelles

The invention discloses novel morphology shifting micelles and amphiphilic coated metal nanofibers. Methods of using and making the same are also disclosed.

Synthesis and cellular properties of Near-IR BODIPY-PEG and carbohydrate conjugates

A series of red and near-IR fluorescent BODIPY conjugates, containing either one or two indolylstyryl groups at the 3- and/or 5-positions and a low molecular weight PEG or carbohydrate group, were synthesized using a Cu(I)-catalyzed azide-alkyne Huisgen cycloaddition ('click' reaction). All BODIPY conjugates show emission and fluorescence quantum yields in the ranges of 642-732 nm and 0.24-0.56, respectively, and Stokes' shifts of ca. 30 nm. In vitro cellular investigations using human carcinoma HEp2 cells showed that all BODIPYs are non-toxic, both in the absence and presence of light (1 J/cm 2), up to 100 μM concentrations. The PEG and galactose conjugates were more efficient at cell internalization than the unconjugated BODIPYs. The mono-indolylstyryl-BODIPYs showed higher cellular uptake (about five-fold) compared with the di-indolylstyryl-BODIPYs, and higher fluorescence quantum yields.