1391405-52-9Relevant articles and documents
An efficient and convenient one-pot multicomponent synthesis of novel pyrimidine derivatives: N-(4-aryl-6-(pyridin-2-yl)pyrimidin-2-yl)cyanamides
Rong, Liangce,Wei, Xianyong,Tao, Shimin,Lu, Yao,Xie, Ruilun,Zhou, Jun,Zong, Zhimin
, p. 1907 - 1916 (2013/06/05)
An efficient and facile synthesis of novel pyrimidine derivatives, N-(4-aryl-6-(pyridin-2-yl)pyrimidin-2-yl)cyanamides, via one-pot multicomponent reaction of different aromatic aldehydes, 2-acetylpyridine, and cyanoguanidine in the presence of NaOH in anhydrous EtOH is reported. Pyrimidine derivatives are extremely important six membered aromatic heterocyclic rings containing two nitrogen atoms which have a wide variety of important biologically activity. This method has the advantages of easy work-up, convenient purification, short reaction times, and high yields.