139163-87-4Relevant articles and documents
Tetrapeptides, as small-sized peptidic inhibitors; synthesis and their inhibitory activity against BACE1
Kakizawa, Taeko,Hidaka, Koushi,Hamada, Daisuke,Yamaguchi, Ryoji,Uemura, Tsuyoshi,Kitamura, Hitomi,Tagad, Harichandra D.,Hamada, Takashi,Ziora, Zyta,Hamada, Yoshio,Kimura, Tooru,Kiso, Yoshiaki
scheme or table, p. 257 - 262 (2011/03/18)
β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is known to be involved in the production of amyloid β-peptide in Alzheimer's disease and is a major target for current drug design. We previously reported substrate-based peptidomimetics, KMI-com
PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE
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Page 37-38, (2008/06/13)
Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
Application of the asymmetric aminohydroxylation reaction for the syntheses of HIV-protease inhibitor, hydroxyethylene dipeptide isostere and γ-amino acid derivative
Kondekar, Nagendra B.,Kandula, Subba Rao V.,Kumar, Pradeep
, p. 5477 - 5479 (2007/10/03)
An enantioselective synthesis of lactone 1, a precursor to the (2R,4S,5S) hydroxyethylene dipeptide isostere and amino acid AHPPA 2 has been accomplished from the common intermediate 5 employing Sharpless asymmetric aminohydroxylation as the key step.
Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3′ residue
Mak, Chi Ching,Le, Van-Duc,Lin, Ying-Chuan,Elder, John H,Wong, Chi-Huey
, p. 219 - 222 (2007/10/03)
A series of norstatine-based HIV/FIV protease inhibitors incorporating a 15-membered macrocycle as a mimic of the tripeptide (Ala-Val-Phe), a motif with a small P3′ residue effective against the FIV protease and the drug-resistant HIV proteases, has been
Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate
Ha, Hyun-Joon,Ahn, Young-Gil,Lee, Gwan Sun
, p. 2327 - 2336 (2007/10/03)
Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate, a key component of the natural product bestatin and HIV protease inhibitors of KNI- 272 and R-87366, has been achieved from the stereoselective aldimine coupling reaction between 3-phenyl-2-aminopropanenitrile and (Z)-α-methoxy trimethylsilyl ketene acetal in the presence of Lewis acids.
Development of selective tight-binding inhibitors of leukotriene A4 hydrolase
Yuan,Munoz,Wong,Haeggstrom,Wetterholm,Samuelsson
, p. 211 - 220 (2007/10/02)
Leukotriene A4 hydrolase is a zinc-containing enzyme which exhibits both epoxide hydrolase and aminopeptidase activities. Since the enzyme product leukotriene B4 is an inflammatory mediator, it is of interest to develop selective inh
A Practical Synthesis of threo-3-Amino-2-hydroxycarboxylic Acids
Matsuda, Fuyuhiko,Mtsumoto, Teruyo,Ohsaki, Masako,Ito, Yoshio,Terashima, Shiro
, p. 360 - 365 (2007/10/02)
An expeditious synthesis of (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid (2) and (2S,3R)-3-amino-2-hydroxy-4-phenylbutyric acid (4), the key components of the renin inhibitor (1) and bestatin (3), respectively, have been accomplished by featuring hi