139163-87-4Relevant articles and documents
Tetrapeptides, as small-sized peptidic inhibitors; synthesis and their inhibitory activity against BACE1
Kakizawa, Taeko,Hidaka, Koushi,Hamada, Daisuke,Yamaguchi, Ryoji,Uemura, Tsuyoshi,Kitamura, Hitomi,Tagad, Harichandra D.,Hamada, Takashi,Ziora, Zyta,Hamada, Yoshio,Kimura, Tooru,Kiso, Yoshiaki
scheme or table, p. 257 - 262 (2011/03/18)
β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is known to be involved in the production of amyloid β-peptide in Alzheimer's disease and is a major target for current drug design. We previously reported substrate-based peptidomimetics, KMI-com
PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE
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Page 37-38, (2008/06/13)
Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.
Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate
Ha, Hyun-Joon,Ahn, Young-Gil,Lee, Gwan Sun
, p. 2327 - 2336 (2007/10/03)
Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate, a key component of the natural product bestatin and HIV protease inhibitors of KNI- 272 and R-87366, has been achieved from the stereoselective aldimine coupling reaction between 3-phenyl-2-aminopropanenitrile and (Z)-α-methoxy trimethylsilyl ketene acetal in the presence of Lewis acids.