139166-80-6

Basic information

• Product Name: BOC-PNA-T-OH
• Synonyms: BOC-PNA-T-OH;N-[2-(BOC-AMINO)ETHYL]-N-(THYMIN-1-YLACETYL)GLYCINE;(BOC-T-AEG-OH)
• CAS NO: 139166-80-6
• Molecular Formula: C₁₆H₂₄N₄O₇
• Molecular Weight: 384.38
• Mol File: 139166-80-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Density: 1.301±0.06 g/cm3(Predicted)
• PKA: 3.33±0.10(Predicted)
• CAS DataBase Reference: BOC-PNA-T-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-PNA-T-OH(139166-80-6)
• EPA Substance Registry System: BOC-PNA-T-OH(139166-80-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 139166-80-6(Hazardous Substances Data)

Usage

General Description

BOC-PNA-T-OH is a chemical compound that is commonly used in the synthesis of peptide nucleic acids (PNA). It consists of a BOC (tert-butoxycarbonyl) protecting group, a PNA backbone with a thymine base, and an hydroxyl group. The BOC protecting group can be removed under mild acidic conditions, allowing for further chemical modification. PNA-T-OH is an important building block in the production of PNA oligomers, which have applications in molecular biology, diagnostics, and therapeutics, due to their high binding affinity and stability. BOC-PNA-T-OH is widely used in the field of peptide nucleic acid research and drug development.

Upstream product

• 152774-08-8 methyl N-[2-(Boc-amino)ethyl]-N-(thymin-1-ylacethyl) glycinate 
• 149411-93-8 N-(2-t-butoxycarbonylaminoethyl)-N-(thymin-1-ylacetyl)glycine ethyl ester 
• 90495-99-1 N-(2-tert-butoxycarbonylaminoethyl)aminoacetic acid 
• 139166-79-3 1-thyminylacetic acid pentafluorophenyl ester 
• 128421-86-3 methyl N-(2-(tert-butyloxycarbonyl)aminoethyl)glycinate 
• 20924-05-4 thymidyl acetic acid 
• 72648-80-7 ethyl 2-[2-(tert-butoxycarbonylamino)ethyl-[3-[[4-(4,5-difluoro-2-methylsulfanyl-phenyl)phenoxy]methyl]benzoyl]amino]acetate 
• 57260-73-8 N-BOC-1,2-diaminoethane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 134456-94-3 methyl (5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethanoate 
• 65-71-4 thymin 

Downstream Products

• 139166-81-7 {(2-tert-Butoxycarbonylamino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid pentafluorophenyl ester 
• 1092571-18-0 C₄₀H₅₈N₂₂O₁₅ 
• 1092571-16-8 C₄₁H₆₀N₂₂O₁₅ 
• 289684-56-6 N-[9-(2-{7-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-3,9-dioxo-1,4,7,10tetraaza-cyclododec-1-yl}-2-oxo-ethyl)-9H-purin-6-yl]-benzamide 
• 289684-54-4 7-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-3,9-dioxo-1,4,7,10tetraaza-cyclododecane-1-carboxylic acid benzyl ester 
• 1026796-74-6 {[(4-benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-amino}-acetic acid 
• 345201-79-8 3-{[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-propionic acid 
• 345201-81-2 2-{[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-propionic acid 
• 345201-80-1 2-{[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-propionic acid 
• 345201-78-7 {[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid 
• 681430-78-4 3-{[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-phenyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-propionic acid methyl ester 
• 345201-73-2 {[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester 
• 169396-92-3 2-(N-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetic acid 
• 289684-71-5 {benzyloxycarbonyl-[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-ethyl]-amino}-acetic acid methyl ester 

Relevant articles and documents

Synthesis and polymerisation of lipophilic peptide nucleic acids derived from stearic acid and pentacosa-10,12-diynoic acid

The adenine, cytosine and thymine peptide nucleic acid (PNA) monomers and PNA T10 oligomers bearing either a diacetylenic or stearoyl moiety at the N- or C-terminus have been successfully prepared. The resulting thymine monomeric and T10/

Pharmaceuticals for enhanced delivery to disease targets

Pharmaceuticals for enhanced delivery to a disease target comprises a pair of compounds. The first compound comprises a first oligopeptide conjugated to a first moiety for coupling with a diagnostic or therapeutic active agent. The second compound comprises a second oligopeptide conjugated to a targeting species having a targeting moiety capable of binding to a target. The second oligopeptide has a sequence that is complementary to a sequence of the first oligopeptide. The first and second oligopeptides can be complementary PNA sequences. The pharmaceuticals are administered into a subject in methods for diagnosing or treating a disease condition, or assessing the effectiveness of a treatment of the disease condition.

PEPTIDE NUCLEIC ACID CONJUGATES

A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.