139221-89-9

Upstream product

• 139221-65-1 2-(α-benzoylamino-p-methoxystyryl)-6,8-dibromo-3,1-benzoxazin-4(H)-one 
• 609-85-8 2-amino-3,5-dibromobenzoic acid 
• 139221-64-0 N-(α-benzoylamino-p-methoxycinnamoyl)-3,5-dibromoanthranilic acid 
• 5429-22-1 4-(4-methoxybenzylidene)-2-phenyl-5(4H)-oxazolone 

Downstream Products

• 139221-90-2 N-[(Z)-1-(2,4-Dibromo-8-oxo-8H-quinazolino[4,3-b]quinazolin-6-yl)-2-(4-methoxy-phenyl)-vinyl]-benzamide 
• 139221-91-3 N-[(Z)-1-(6,8-Dibromo-4-thioureido-quinazolin-2-yl)-2-(4-methoxy-phenyl)-vinyl]-benzamide 
• 139221-92-4 N-[(Z)-1-(6,8-Dibromo-1,2,3,3a,5-pentaaza-cyclopenta[a]naphthalen-4-yl)-2-(4-methoxy-phenyl)-vinyl]-benzamide 

Relevant academic research and scientific papers

Steric and polar factors involving heteroring opening of 2-(α-benzoylamino-p-methoxystyryl)-6,8-dibromo-3,1-benzoxazin-4(H)-one

2-(α-Benzoylamino-p-methoxystyryl)-6,8-dibromo-3,1-benzoxazin-4(H)-one (IIa) has been prepared by the reaction of 4-(p-methoxybenzylidene)-2-phenyloxazol-5-one with 3,5-dibromoanthranilic acid in acetic acid followed by cyclisation in acetic anhydride.Reactions of IIa with amines, ethylacetoacetate, NaN3, P2S5, ammonium acetate and maleic anhydride have been studied.Friedel-Crafts' reaction on IIa with benzene and toluene gives VII.Hydrazinolysis of IIa with hydrazine hydrate and phenylhydrazine in n-butanol affords IVa,b.Reactions of IVa with aldehydes, aceticanhydride, and benzoyl chloride gives V, XVIIIa and XVIIIb, respectively.Treatment of X with a mixture of PCl5 and POCl3 gives XIII.Reaction of XIII with anthranilic acid, thiourea and NaN3 affords XIV, XV and XVI respectively.Mannich reaction on X with different bases gives the Mannich bases (XI) while methylation of X with methyl iodide in alkaline medium gives XII.