5429-22-1

Basic information

• Product Name: 4-(4-METHOXYBENZYLIDENE)-2-PHENYL-2-OXAZOLIN-5-ONE
• Synonyms: (4E)-4-[(4-methoxyphenyl)methylidene]-2-phenyl-1,3-oxazol-5-one
• CAS NO: 5429-22-1
• Molecular Formula: C₁₇H₁₃NO₃
• Molecular Weight: 279.2981
• Mol File: 5429-22-1.mol
• Article Data: 83

Chemical Properties

• Melting Point: 160 °C
• Boiling Point: 434.8°Cat760mmHg
• Flash Point: 196.2°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 9.2E-08mmHg at 25°C
• Refractive Index: 1.594
• PKA: -0.18±0.20(Predicted)
• CAS DataBase Reference: 4-(4-METHOXYBENZYLIDENE)-2-PHENYL-2-OXAZOLIN-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHOXYBENZYLIDENE)-2-PHENYL-2-OXAZOLIN-5-ONE(5429-22-1)
• EPA Substance Registry System: 4-(4-METHOXYBENZYLIDENE)-2-PHENYL-2-OXAZOLIN-5-ONE(5429-22-1)

Safety Data

• Hazardous Substances Data: 5429-22-1(Hazardous Substances Data)

Usage

General Description

4-(4-Methoxybenzylidene)-2-phenyl-2-oxazolin-5-one is a chemical compound with the molecular formula C19H15NO3. It belongs to the oxazolinone class of compounds and contains a benzylidene group and a 4-methoxy substituent. It is commonly used as a reagent in organic synthesis and in the pharmaceutical industry for the production of various drugs. 4-(4-METHOXYBENZYLIDENE)-2-PHENYL-2-OXAZOLIN-5-ONE has been studied for its potential biological and medicinal properties, including its antimicrobial, antifungal, and anticancer activities. Its structural characteristics and chemical reactivity make it a valuable building block in the synthesis of complex organic molecules.

InChI:InChI=1/C17H13NO3/c1-20-14-9-7-12(8-10-14)11-15-17(19)21-16(18-15)13-5-3-2-4-6-13/h2-11H,1H3/b15-11+

Upstream product

• 495-69-2 Hippuric Acid 
• 127-09-3 sodium acetate 
• 108-24-7 acetic anhydride 
• 123-11-5 4-methoxy-benzaldehyde 
• 211808-98-9 3-(ethoxycarbonyl)benzotriazol-1-oxide 
• 105-13-5 4-Methoxybenzyl alcohol 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 4231-62-3 1-benzoyl-1H-benzotriazole 
• 532-94-5 sodium hippurate 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 
• 5356-71-8 1,3-diphenyl-1H-pyrazol-5-amine 
• 33402-67-4 sodium hydroxy(4-methoxyphenyl)methanesulfonate 
• 19747-00-3 2-benzoylamino-3-(4-methoxy-phenyl)-acryloyl azide 

Downstream Products

• 57427-93-7 2-phenyl-4-<α-E-p-methoxyphenylethylidene>-5(4H)-oxazolone 
• 15427-02-8 1t-(4-methoxy-phenyl)-5-phenyl-(3rN)-6-oxa-4-aza-spiro[2.4]hept-4-en-7-one 
• 15427-02-8 (1S,3S)-1-(4-Methoxy-phenyl)-5-phenyl-6-oxa-4-aza-spiro[2.4]hept-4-en-7-one 
• 138973-11-2 1,4-Bis(5'-(4-methoxybenzylidene)-2'-phenyl-4'-imidazolinone-3'-ylamino)phthalazine 
• 75437-11-5 (Z)-N-benzoylamino-3-(4-methyoxyphenyl) acrylic acid methyl ester 
• 1252042-87-7 C₂₄H₁₅Cl₂N₃O₂S 
• 201989-25-5 C₂₂H₂₄N₂O₃ 
• 1323140-64-2 (Z)-N-(1-chloro-1-(4-methoxyphenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide 
• 130087-65-9 N-[7-(4-Methoxy-phenyl)-5-oxo-3-phenyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3]thiazin-6-yl]-benzamide 
• 92265-05-9 N-[1-Hydroxymethyl-2-(4-methoxy-phenyl)-ethyl]-benzimidic acid 
• 132653-52-2 2-(p-methoxybenzyl)-2-benzamidoethylamine 
• 97856-45-6 N-[(E)-1-Hydroxymethyl-2-(4-methoxy-phenyl)-vinyl]-benzamide 
• 81820-43-1 N-Acetyl-4-{4-[1-(4-methoxy-phenyl)-meth-(Z)-ylidene]-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl}-benzenesulfonamide 

Relevant articles and documents

Synthesis, characterization, swelling and antimicrobial efficacies of chemically modified chitosan biopolymer

Three heterocyclic compounds namely: (Z)-4-benzylidene-2-phenyl-1,3-oxazol-5-one (A), (Z)-4-(4-methoxybenzylidene)-2-phenyl-1,3-oxazol-5-one (B), (Z)-4-(2-thienyl methylene)-2-phenyl-1,3-oxazol-5-one (C) were prepared in one step reaction between hippuric

Novel Approach to the Synthesis of 3-amino-4-arylpyridin-2(1H)-one Derivatives

[Figure not available: see fulltext.] The reaction of 4-arylidene-2-phenyloxazol-5(4H)-ones with enamines of ethyl acetoacetate gave 4-aryl-2-methyl-6-oxo-5-[(phenylcarbonyl)amino]-1,4,5,6-tetrahydropyridine-3-carboxylic acid esters, which, when heated with phosphorus oxychloride, were converted into esters of 7-aryl-5-methyl-2-phenyloxazolo[5,4-b]pyridine-6-carboxylic acids. Alkaline hydrolysis of these compounds gave 4-aryl-2-methyl-6-oxo-5-[(phenylcarbonyl)amino]-1,6-dihydropyridine-3-carboxylic acid esters.

Synthesis, assessment and corrosion protection investigations of some novel peptidomimetic cationic surfactants: Empirical and theoretical insights

Three novel peptidomimetic cationic surfactants were synthesized in good yields. The chemical configurations of these surfactants were clarified using 1H, 13C NMR and FT-IR spectroscopy. The inhibition capacity and adsorption performance of these compounds on C-steel were studied by electrochemical techniques (Electrochemical impedance spectroscopy (EIS) and Potentiodynamic polarization (PDP) methods). The prepared compounds demonstrated outstanding protection power for the erosion of C-steel in 0.5 M HCl at 323 K. The PDP studies demonstrated that the novel surfactants behaved as mixed-type additives. The protection capacity rises with an increasing surfactant dose, with values ranging from 93.10 to 98.25percent at 100 ppm. The adsorption of additives on the electrode interface follows the Langmuir model and contains chemisorption modes. The Monte Carlo (MD) simulations and density functional theory (DFT) calculations support the experimental findings and provide insight into the understanding of the adsorption features and protection performance mechanisms of the examined surfactants.