139225-06-2Relevant academic research and scientific papers
α-Phenylglycinol as chiral auxiliary in diastereoselective Strecker synthesis of α-amino acids
Chakraborty,Azhar Hussain,Venkat Reddy
, p. 9179 - 9190 (2007/10/02)
The high diastereoselectivity achieved in Strecker synthesis using inexpensive α-phenylglycinol as chiral auxiliary and its facile removal by oxidative clearange make it an ideal choice for the large scale preparations of optically active α-amino acids specially α-arylglycines present abundantly in glycopeptide antibiotics. A number of chiral amino acids are synthesized following this method. Also molecular mechanics calculations are carried out to explain the observed diastereoselection.
Diastereoselective Strecker Synthesis using α-Phenylglycinol as Chiral Auxiliary
Chakraborty, T. K.,Reddy, G. V.,Hussain, K. Azhar
, p. 7597 - 7600 (2007/10/02)
Use of α-phenylglycinol as chiral auxiliary in Strecker synthesis ensures high diastereoselectivity and its easy removal by oxidative cleavage allows large scale preparation of optically active α-amino acids.
