139229-58-6

Basic information

• Product Name: 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid
• Synonyms: 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid
• CAS NO: 139229-58-6
• Molecular Formula: C₁₀H₈F₂O₂
• Molecular Weight: 198.1661264
• Product Categories: Carboxylic Acids;Phenyls & Phenyl-Het
• Mol File: 139229-58-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 305.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.451±0.06 g/cm3(Predicted)
• PKA: 3?+-.0.20(Predicted)
• CAS DataBase Reference: 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid(139229-58-6)
• EPA Substance Registry System: 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid(139229-58-6)

Safety Data

• Hazardous Substances Data: 139229-58-6(Hazardous Substances Data)

Usage

General Description

1-(2,6-difluorophenyl)cyclopropanecarboxylic acid is a chemical compound with the molecular formula C11H10F2O2. It is a cyclopropane derivative with a carboxylic acid functional group and two fluorine substituents on the phenyl ring. 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid is used in the synthesis of pharmaceuticals and agrochemicals due to its potential as a building block for more complex organic molecules. Additionally, it may have applications in the development of materials and other industrial processes. The precise properties and applications of 1-(2,6-difluorophenyl)cyclopropanecarboxylic acid depend on its chemical reactivity and interaction with other substances.

Upstream product

• 654-01-3 (2,6-difluorophenyl)acetonitrile 
• 124276-65-9 1-(2,6-difluorophenyl)cyclopropane-1-carbonitrile 

Downstream Products

• 1427380-04-8 C₁₀H₁₁F₂N*ClH 
• 1346641-12-0 N-(4-cyano-2,3,5,6-tetrafluorophenyl)-1-(2,6-difluorophenyl)cyclopropanecarboxamide 

Relevant articles and documents

Synthesis and antiviral properties of new derivatives of 2-(alkylsulfanyl)-6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methylpyrimidin-4(3H)-one

Based on 2-(2,6-difluorophenyl)acetonitrile a synthesis was performed of new bioisosteric prochiral analogs of anti-HIV-1 active derivatives of 2-alkoxy-6-benzylpyrimidin-4(3Н)-one that we had previously obtained. The study using infected and nonifected strains of cells MT-4 made it possible to find in all prepared compounds a high anti-HIV activity whereas the cytotoxicity of the substances depended strongly on the structure of the alkylsulfanyl fragment of the molecule.

1,3-SUBSTITUED PYRAZOLE COMPOUNDS USEFUL FOR REDUCTION OF VERY LONG CHAIN FATTY ACIC LEVELS

Disclosed are chemical entities which are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Formula (I) has the structure: R1a, R1b, R2, R3, R4a, R4b and Y are as defined herein. These chemical entities are useful for reduction of very long chain fatty acid levels. These chemical entities and pharmaceutically acceptable compositions comprising such chemical entities can be useful for treating various diseases, disorders and conditions, such as adrenoleukodystrophy (ALD).

Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes

Systematic ligand development has led to the identification of novel mono-N-protected amino acid ligands for Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes. A diverse range of organoboron reagents can be used as coupling partners, and the reaction proceeds under mild conditions. These results provide a new retrosynthetic disconnection for the construction of enantioenriched cis-substituted cyclopropanecarboxylic acids.