139237-78-8

Basic information

• Product Name: (R,R)-(+)-trans-4,5-diphenylimidazoline-2-thione
• Synonyms: (R,R)-(+)-trans-4,5-diphenylimidazoline-2-thione
• CAS NO: 139237-78-8
• Molecular Weight: 254.356
• Mol File: 139237-78-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (R,R)-(+)-trans-4,5-diphenylimidazoline-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: (R,R)-(+)-trans-4,5-diphenylimidazoline-2-thione(139237-78-8)
• EPA Substance Registry System: (R,R)-(+)-trans-4,5-diphenylimidazoline-2-thione(139237-78-8)

Safety Data

• Hazardous Substances Data: 139237-78-8(Hazardous Substances Data)

Upstream product

• 35132-20-8 (R,R)-1,2-diphenylethylenediamine 
• 67-66-3 chloroform 
• 16099-67-5 trans-4,5-diphenylimidazolidine-2-thione 
• 1262241-05-3 C₂₈H₃₀N₂OS 
• 851913-12-7 pentafluorophenyl (S)-2-(4-isobutylphenyl)propionate 
• 522-34-9 Diphenylglyoxime 
• 5700-60-7 1,2-Diphenylethylenediamine 
• 75-15-0 carbon disulfide 
• 951-87-1 rac-1,2-diphenylethylene-1,2-diamine 

Downstream Products

• 137638-30-3 1,3-di(2-benzylbutanoyl)-trans-4,5-diphenylimidazolidine-2-thione 
• 137618-05-4 1,3-dipropionyl-trans-4,5-diphenylimidazolidine-2-thione 
• 1262241-07-5 C₂₄H₂₂N₂OS 
• 1262241-06-4 C₂₉H₂₆N₂O₂S 
• 1262241-04-2 C₂₅H₂₄N₂OS 
• 1262241-17-7 C₂₅H₂₄N₂OS 
• 1262241-05-3 C₂₈H₃₀N₂OS 
• 246868-60-0 (4S,5S)-4,5-diphenylimidazolidine-2-thione 
• 114937-30-3 (2S)-2-<4-(2-Methylpropyl)phenyl>propan-1-ol 
• 1262241-10-0 C₂₈H₃₀N₂OS 
• 1262241-11-1 C₄₁H₄₆N₂O₂S 

Relevant articles and documents

Reaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines

The reaction of thiocarbonyl fluoride, generated from difluorocarbene, with various amines under mild conditions is described. Secondary amines, primary amines, and o-phenylenediamines are converted to thiocarbamoyl fluorides, isothiocyanates, and difluoromethylthiolated heterocycles, respectively. Thiocarbamoyl fluorides were further transformed into trifluoromethylated amines by using a one-pot process. Thiocarbonyl fluoride is generated in situ and is rapidly fully converted in one pot under mild conditions; therefore, no special safety precautions are needed.

Resolution of (4RS,5RS)-4,5-diphenylimidazolidine-2-thione using pentafluorophenyl active esters

(4RS,5RS)-4,5-Diphenylimidazolidine-2-thione is resolved efficiently by treatment with NaHMDS and an enantiomerically pure pentafluorophenyl active ester. The levels of diastereocontrol were excellent (up to 90% de).

Heterocyclic compounds as P2X7 ion channel blockers

The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: 1 wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer''s disease, etc.