13924-50-0

Usage

Uses

Used in Pharmaceutical Industry:
BENZYLIDENE 2-FLUORENAMINE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drug candidates and bioactive molecules.
Used in Organic Chemistry Research:
In the realm of organic chemistry, BENZYLIDENE 2-FLUORENAMINE serves as a valuable compound for research purposes, aiding in the exploration and understanding of chemical reactions and mechanisms involving benzylidene and 2-fluorenamine moieties.

InChI:InChI=1/C20H15N/c1-2-6-15(7-3-1)14-21-18-10-11-20-17(13-18)12-16-8-4-5-9-19(16)20/h1-11,13-14H,12H2/b21-14+

Upstream product

• 153-78-6 2-aminofluorene 
• 100-52-7 benzaldehyde 
• 6554-98-9 trans-4-Hydroxystilbene 
• 67823-52-3 2-azido-9H-fluorene 
• 100-42-5 styrene 

Relevant academic research and scientific papers

Iron-Catalyzed Nitrene Transfer Reaction of 4-Hydroxystilbenes with Aryl Azides: Synthesis of Imines via C=C Bond Cleavage

C=C bond breaking to access the C=N bond remains an underdeveloped area. A new protocol for C=C bond cleavage of alkenes under nonoxidative conditions to produce imines via an iron-catalyzed nitrene transfer reaction of 4-hydroxystilbenes with aryl azides is reported. The success of various sequential one-pot reactions reveals that the good compatibility of this method makes it very attractive for synthetic applications. On the basis of experimental observations, a plausible reaction mechanism is also proposed.

A benzo-15-crown-5-modifying ratiometric-absorption and fluorescent OFF-ON chemosensor for Cu2 +

One new benzo-15-crown-5-modifying fluorene Schiff base (FBC), together with the C=N-linked fluorene-3,4-dimethoxybenzene (FBDMO) and fluorene-benzene (FB) references, has been designed and facilely synthesized. The binding of Cu2 + with nitrogen atom of C=N moiety in these three compounds can inhibit the photo-induced electronic transition process and induce the ratiometric-absorption and fluorescent OFF-ON response to Cu2 +. Whereas the employment of benzo-15-crown-5 moiety in FBC as additional binding platform for Cu2 + not only amplifies the fluorescent enhancement of FBC via preventing the isomerization of C=N moiety, but also endows this compound high selectivity and rapid response towards Cu2 + over the references FB and FBDMO. These results render FBC highly sensitive ratiometric-absorption and fluorescent OFF-ON detecting potential for Cu2 + with the detection limit of 3.91 × 10- 6 M.