139264-24-7

Basic information

• Product Name: Zolmitriptan
• Synonyms: Zolmitriptan R-Isomer (20 mg) ((R)-4-({3-[2-(Dimethylamino)ethyl]indol-5-yl}methyl)oxazolidin-2-one);ZolMitriptan R-IsoMer;(R)-4-[[3-[2-(DiMethylaMino)ethyl]-1H-indol-5-yl]Methyl]-2-oxazolidinone (ZolMitriptan R-IsoMer);(4R)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone;(R)-4-({3-[2-(Dimethylamino)ethyl]indol-5-yl}methyl)oxazolidin-2-one
• CAS NO: 139264-24-7
• Molecular Formula: C16H21N3O2
• Molecular Weight: 287.35684
• Product Categories: ZOLMITRIPTAN;Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 139264-24-7.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Water (Slightly)
• CAS DataBase Reference: Zolmitriptan(CAS DataBase Reference)
• NIST Chemistry Reference: Zolmitriptan(139264-24-7)
• EPA Substance Registry System: Zolmitriptan(139264-24-7)

Safety Data

• Hazardous Substances Data: 139264-24-7(Hazardous Substances Data)

Usage

Uses

(R)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone, is an isomer of Zolmitriptan (Z639000), a Serotonin 5HTID-receptor agonist.

Upstream product

• 50-00-0 formaldehyd 
• 139264-15-6 (S)-2-<5-<(2-oxo-1,3-oxazolidin-4-yl)methyl>-1H-indol-3-yl>ethylamine 
• 191864-24-1 ethyl 3-(2-dimethylaminoethyl)-5-[(4S)-2-oxooxazolidin-4-ylmethyl]-1H-indole-2-carboxylate 
• 1456594-06-1 ethyl 3-(2-dimethylaminoethyl)-5-[(4R)-2-oxooxazolidin-4-ylmethyl]-1H-indole-2-carboxylate 
• 152305-23-2 (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 19718-92-4 4-(N,N-dimethylamino)butyraldehyde dimethyl acetal 
• 187975-62-8 (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one 
• 139264-19-0 Zolmitriptan hydrochloride 
• 1116-77-4 4,4-diethoxy-N,N-dimethyl-1-butanamine 
• 868622-23-5 ethyl (S)-3-(2-(dimethylamino)ethyl)-5-((2-oxazolidin-4-yl)methyl)-1H-indolecarboxylate hydrochloride 
• 659738-69-9 (S)-3-(2-dimethylaminoethyl)-5-[2-oxo-1,3-oxazolidin-4-ylmethyl]-1H-indol-2-carboxylic acid 
• 139264-57-6 (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride 

Downstream Products

• 251451-30-6 Zolmitriptan N-oxide 

Relevant articles and documents

PROCESS FOR PREPARATION OF ZOLMITRIPTAN

The present invention provides a convenient and industrially viable process for preparation of Zolmitriptan (I) having desired purity. The invention specifically relates to a method for isolating (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride (IIIa) of desired purity by separating the undesired inorganic side products such as stannous hydroxide by manipulation of pH at different stages and finally treating with N,N-dimethylamino butyraldehyde diethyl acetal in an acidic medium to provide Zolmitriptan (I) conforming to regulatory specifications.

Synthesis of zolmitriptan and related substances

Efficient and cost-effective synthesis of Zolmitriptan 1 employing Japp-Klingemann reaction and a new robust purification strategy is described.

ORALLY DISINTEGRATING TABLETS OF ZOLMITRIPTAN AND PROCESS FOR PREPARING THE SAME

Silicon dioxide free orally disintegrating tablet formulations of zolmitriptan or a pharmaceutically acceptable salt thereof having magnesium carbonate heavy and sodium stearyl fumarate with one or more pharmaceutically acceptable excipients and a process for preparing such a formulation and its use in the treatment of migraines.