1392833-89-4

Upstream product

• 106-41-2 4-bromo-phenol 
• 27187-13-9 5-chloro-[1,2,4]triazolo[4,3-a]pyridine 
• 5193-03-3 (6-chloropyridin-2-yl)hydrazine 

Relevant academic research and scientific papers

Synthesis and studies on the anticonvulsant activity of 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives

In this study, a series of new 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives was synthesized and their anticonvulsant activity and neurotoxicity was evaluated with the maximal electroshock and rotarod tests, respectively. The most promising compounds, 3p (5-(4-chlorophenoxy)-[1,2,4]triazolo[4,3-a] pyridine) and 3r (5-(4-bromophenoxy)-[1,2,4]triazolo[4,3-a]pyridine), showed a median effective dose of 13.2 and 15.8 mg/kg and had a protective index value of 4.8 and 6.9, respectively. For exploring the putative mechanism of action, compounds 3n, 3p and 3r were tested in chemically induced models. Georg Thieme Verlag KG Stuttgart.New York.