27187-13-9 Usage
General Description
5-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRIDINE is an organic compound with molecular formula C6H4ClN5. It is a heterocyclic compound that contains a triazole ring fused to a pyridine ring with a chlorine atom attached to the 5 position of the triazole ring. This chemical is used in the pharmaceutical industry as a building block for the synthesis of various biologically active compounds, such as fungicides, herbicides, and insecticides. It is also used as a research reagent and in the development of new pharmaceuticals. The compound has potential applications in the treatment of various diseases and as a tool for chemical biology research. However, it should be handled and used with proper care and in accordance with safety guidelines due to its potential hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 27187-13-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,1,8 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 27187-13:
(7*2)+(6*7)+(5*1)+(4*8)+(3*7)+(2*1)+(1*3)=119
119 % 10 = 9
So 27187-13-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H4ClN3/c7-5-2-1-3-6-9-8-4-10(5)6/h1-4H
27187-13-9Relevant articles and documents
Synthesis and studies on the anticonvulsant activity of 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives
Guan,Zhang,Sun,Chang,Sui
, p. 372 - 377 (2012/10/29)
In this study, a series of new 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives was synthesized and their anticonvulsant activity and neurotoxicity was evaluated with the maximal electroshock and rotarod tests, respectively. The most promising compounds, 3p (5-(4-chlorophenoxy)-[1,2,4]triazolo[4,3-a] pyridine) and 3r (5-(4-bromophenoxy)-[1,2,4]triazolo[4,3-a]pyridine), showed a median effective dose of 13.2 and 15.8 mg/kg and had a protective index value of 4.8 and 6.9, respectively. For exploring the putative mechanism of action, compounds 3n, 3p and 3r were tested in chemically induced models. Georg Thieme Verlag KG Stuttgart.New York.
