27187-13-9 Usage
Uses
Used in Pharmaceutical Industry:
5-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRIDINE is used as a building block for the synthesis of various biologically active compounds, including fungicides, herbicides, and insecticides. Its unique structure contributes to the development of new pharmaceuticals with potential applications in treating a range of diseases.
Used in Research and Development:
5-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRIDINE serves as a research reagent, facilitating the exploration of new chemical entities and their potential therapeutic effects. It is instrumental in chemical biology research, aiding scientists in understanding the interactions between small molecules and biological targets.
Used in Chemical Biology Research:
5-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRIDINE is utilized as a tool in chemical biology to study the mechanisms of action of drugs and their effects on biological systems. Its structural features make it a valuable probe for investigating molecular recognition and signaling pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 27187-13-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,1,8 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 27187-13:
(7*2)+(6*7)+(5*1)+(4*8)+(3*7)+(2*1)+(1*3)=119
119 % 10 = 9
So 27187-13-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H4ClN3/c7-5-2-1-3-6-9-8-4-10(5)6/h1-4H
27187-13-9Relevant academic research and scientific papers
Synthesis and studies on the anticonvulsant activity of 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives
Guan,Zhang,Sun,Chang,Sui
, p. 372 - 377 (2012/10/29)
In this study, a series of new 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives was synthesized and their anticonvulsant activity and neurotoxicity was evaluated with the maximal electroshock and rotarod tests, respectively. The most promising compounds, 3p (5-(4-chlorophenoxy)-[1,2,4]triazolo[4,3-a] pyridine) and 3r (5-(4-bromophenoxy)-[1,2,4]triazolo[4,3-a]pyridine), showed a median effective dose of 13.2 and 15.8 mg/kg and had a protective index value of 4.8 and 6.9, respectively. For exploring the putative mechanism of action, compounds 3n, 3p and 3r were tested in chemically induced models. Georg Thieme Verlag KG Stuttgart.New York.
2-AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS
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Page/Page column 119, (2008/12/04)
Provided are compounds that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
