139286-83-2Relevant academic research and scientific papers
2′(3α-Benzyloxy-24-norcholan-23-yl)-2′,4′4′- trimethyl-4′,5′-dihydrooxazoline-N-oxyl as a potential spin probe for model membranes
Banerjee, Sharmila,Trivedi, Girish K.,Srivastava, Sudha,Phadke, Ratna S.
, p. 377 - 382 (2007/10/02)
A new steroidal doxyl (4,4-dimethyloxazolidine-N-oxyl) nitroxide (SDN) viz, 2′-(3α-benzyloxy-24-norcholan-2′-yl)-2′, 4′4′-trimethyl-4′,5′-dihydrooxazoline-N-oxyl has been synthetized. This is expected to have higher mobility over other spin labels reported earlier. The localization of this spin probe in lipid bilayers has been determined using 1H NMR and 31P NMR techniques. The alterations induced by drugs in the membrane characteristics such as phase transition and permeability have been investigated using electron paramagnetic resonance (EPR) techniques. The results show the applicability of SDN as a potential spin probe in the study of biomembranes.
SYNTHESIS OF 2'-(3α-BENZYLOXY-24-NORCHOLAN-23-YL)-2',4',4'-TRIMETHYL-4',5'-DIHYDROOXAZOLINE-N-OXYL - A NEW POTENTIAL SPIN PROBE FOR BIOMEMBRANES
Banerjee, Sharmila,Desai, Umesh R.,Trivedi, Girish K.
, p. 133 - 148 (2007/10/02)
The synthesis of a new steroidal nitroxide, viz. 2'-(3α-benzyloxy-24-norcholan-23-yl)-2',4',4'-trimethyl-4',5'-dihydrooxazoline-N-oxyl 7, a potential spin probe for biomembranes is described.The title compound in improved yield could be obtained by a direct Grignard reaction on the oxaziridine 4.This effected a one-step reduction in the overall synthetic sequence.The methodology of the Grignard reaction on the oxaziridine to yield the nitroxide is reported for the first time.In dilute solutions, the isotropic ESR parameters for 7 have been measured.
