139290-72-5

Basic information

• Product Name: Methanone, (2,3-dimethoxyphenyl)-4-piperidinyl-
• CAS NO: 139290-72-5
• Molecular Formula: C14H19NO3
• Molecular Weight: 249.31
• Mol File: 139290-72-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Methanone, (2,3-dimethoxyphenyl)-4-piperidinyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2,3-dimethoxyphenyl)-4-piperidinyl-(139290-72-5)
• EPA Substance Registry System: Methanone, (2,3-dimethoxyphenyl)-4-piperidinyl-(139290-72-5)

Safety Data

• Hazardous Substances Data: 139290-72-5(Hazardous Substances Data)

Upstream product

• 243640-36-0 4-(2,3-dimethoxybenzoyl)piperidine hydrochloride 
• 139290-70-3 tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 
• 498-94-2 isonipecotic acid 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 280115-99-3 tert-butyl 4-(chlorocarbonyl)-piperidine-1-carboxylate 
• 139290-73-6 4-(2,3-dimethoxyphenyl)-4-piperidinylmethanone trifluoroacetate 
• 100-48-1 pyridine-4-carbonitrile 
• 139290-71-4 4-(2,3-Dimethoxybenzoyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester 

Downstream Products

• 243640-29-1 4-[1-oxo-1-(2,3-dimethoxyphenyl)methyl]-N-2-(4-fluorophen-1-oxo-ethyl)piperidine 
• 252364-39-9 4-[1-oxo-1-(2,3-dimethoxyphenyl)methyl]-N-2-(4-fluorophenylethyl)piperidine 
• 243640-19-9 (2,3‐dimethoxyphenyl)(piperidine‐4‐yl)methanol 
• 311348-76-2 (S)-(-)-α-(2,3-dimethoxyphenyl)-4-piperidinemethanol 
• 1253641-22-3 3-(2-(4-(2,3-dimethoxybenzoyl)-piperidin-1-yl)-ethyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 1253641-28-9 C₁₆H₂₄N₂O₃ 
• 1253641-25-6 C₂₁H₃₂N₂O₅ 
• 175673-57-1 (-)-MDL 100907 
• 139290-65-6 R-(+)-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol 
• 140235-25-2 (+/-)-α-(2,3-dimethoxyphenyl)-4-piperidinemethanol 

Relevant articles and documents

Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand

Ir complexes of chiral phosphine-diamine ligands catalyse the hydrogenation and transfer hydrogenation of aryl-piperidin-4-yl methanones, and ketones bearing both an aryl group and secondary alkyl substituent with up to 98% e.e., and with substrate to catalyst ratios of up to 4000.

COMBINATION OF A HYPNOTIC AGENT AND R (+)-ALPHA-(2,3-DIMETHOXY-PHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL AND THERAPEUTIC APPLICATION THEREOF

The invention concerns the combination of a short-acting hypnotic agent and R-(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol (Compound A) or its prodrug having the Formula II: wherein R is C1-C20 alkyl o

Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol

The present invention provides various processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme: