139326-18-4Relevant academic research and scientific papers
INHIBITORS OF MICROBIAL BETA-GLUCURONIDASE ENZYMES AND USES THEREOF
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Page/Page column 57; 58, (2018/02/28)
Compounds and compositions are provided that comprise selective b-glucuronidase inhibitors. The compounds and compositions can ameliorate the side effects of chemotherapeutic agents and can improve the efficacy of such agents, including irinotecan and non-steroidal anti-inflammatory drugs.
INHIBITORS OF MICROBIAL BETA-GLUCURONIDASE ENZYMES AND USES THEREOF
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Page/Page column 67, (2018/08/26)
Methods utilizing compounds and compositions are provided that comprise selective β-glucuronidase inhibitors. The methods can ameliorate the side effects of chemotherapeutic agents and can improve the efficacy of such agents, including irinotecan and non-steroidal anti-inflammatory drugs. The methods comprise administering the compounds in combination with agents or administering the compounds in a monotherapy for the treatment of cancer and gastrointestinal conditions.
Synthesis and characterization of 6-(aryl)-2-thioxo-1,2-dihydropyridine-3- carbonitriles
Attaby, Fawzy A.,El-Ghandour, Ahmed H.,Sayed, Abdelwahed R.,El Bassuony, Ashraf A.,El-Reedy, Ahmed A.M.
, p. 197 - 221 (2012/06/01)
In the present study, 3-aminothieno[2,3-b]pyridines, pyrido[3′, 2′:4,5]thieno[3,2-d]pyrimidinones, and pyrido[3′,2′:4,5] thieno[3,2-d][1,3]oxazinones were prepared via the reaction of 6-(aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitriles with active-halog
