76993-15-2

Upstream product

• 92126-72-2 2-mercapto-6-phenylpyridine-3-carbonitrile 
• 79-07-2 Chloroacetamide 
• 310456-45-2 2-[(3-cyano-6-phenylpyridin-2-yl)sulfanyl]acetamide 
• 92126-72-2 6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 

Downstream Products

• 76993-14-1 4-Hydroxy-7-phenylpyrido[3',2':4,5]thieno[3,2-d]-1,2,3-triazine 
• 1374993-46-0 7-phenyl-2-thioxo-2,3-dihydropyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(1H)-one 
• 139326-18-4 7-phenylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one 
• 76993-14-1 7-phenylpyrido[3',2':4,5]thieno[3,2-d][1,2,3]triazin-4(3H)-one 
• 139326-20-8 4-Chloro-7-phenyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine 

Relevant academic research and scientific papers

INHIBITORS OF MICROBIAL BETA-GLUCURONIDASE ENZYMES AND USES THEREOF

Compounds and compositions are provided that comprise selective b-glucuronidase inhibitors. The compounds and compositions can ameliorate the side effects of chemotherapeutic agents and can improve the efficacy of such agents, including irinotecan and non-steroidal anti-inflammatory drugs.

INHIBITORS OF MICROBIAL BETA-GLUCURONIDASE ENZYMES AND USES THEREOF

Methods utilizing compounds and compositions are provided that comprise selective β-glucuronidase inhibitors. The methods can ameliorate the side effects of chemotherapeutic agents and can improve the efficacy of such agents, including irinotecan and non-steroidal anti-inflammatory drugs. The methods comprise administering the compounds in combination with agents or administering the compounds in a monotherapy for the treatment of cancer and gastrointestinal conditions.

Synthesis, preliminary structure-activity relationships, and in vitro biological evaluation of 6-aryl-3-amino-thieno[2,3-b]pyridine derivatives as potential anti-inflammatory agents

In our previous study, a series of 6-aryl-3-amino-thieno[2,3-b]pyridine derivatives exhibited potent antiproliferative activities and an unique hepatocellular carcinoma (HCC)-specific anticancer activity was also observed. In further anti-inflammatory research, thienopyridine derivative 1a showed potent inhibition of nitric oxide (NO) production. So a series of thienopyridine analogues of 1a were synthesized and evaluated for anti-inflammatory activities. The structure-activity relationships (SARs) revealed that the most potent analogues 1f and 1o were identified as potent inhibitors of NO production with IC50 values of 3.30 and 3.24 μM, respectively. These results suggest that these 6-aryl-3-amino-thieno[2,3-b]pyridine derivatives might potentially constitute a novel class of anti-inflammatory agents, which require further studies.

Synthesis and characterization of 6-(aryl)-2-thioxo-1,2-dihydropyridine-3- carbonitriles

In the present study, 3-aminothieno[2,3-b]pyridines, pyrido[3′, 2′:4,5]thieno[3,2-d]pyrimidinones, and pyrido[3′,2′:4,5] thieno[3,2-d][1,3]oxazinones were prepared via the reaction of 6-(aryl)-2-thioxo-1,2-dihydropyridine-3-carbonitriles with active-halog

Synthesis of 3-alkyl-2-amino-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-4-ones from 3-ethoxycarbonylamino-thieno[2,3-b]pyridine-2-carboxylic esters and 2-carboxamides

The reaction of 3-ethoxycarbonylamino-thieno[2,3-b]pyridin-2-carboxamides D and especially of the corresponding carboxylic esters B with amines yielded the 3-alkyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4-diones E. These compounds were transformed by

Pyridothieno-N-triazines: A New Series of Orally Active Antiallergic Agents

A new series of orally active mediator release inhibitors, pyridothieno-N-triazines, was synthesized and evaluated for antiallergic activity.Several products showed high activity as inhibitors or wheal information in the rat passive cuta