139331-59-2

Upstream product

• 139331-40-1 6-(3-bromopropyl)-6H-1,3-dioxolo[4,5-g][1,4]benzothiazin-7(8H)-one 
• 2252-63-3 1-(4-Fluorophenyl)piperazine 
• 50995-48-7 methyl 2,5-dibromovalerate 
• 139331-79-6 6-aminobenzo[d][1,3]dioxole-5-thiol 
• 65069-55-8 1-(benzo[d][1,3]dioxol-5-yl)thiourea 
• 50850-94-7 [1,3]dioxolo[4’,5’:4,5]benzo[1,2-d]thiazol-6-amine 

Relevant academic research and scientific papers

Synthesis and biological activities of new 1,4-benzothiazine derivatives

New 2H-1,4-benzothiazin-3(4H)-one derivatives possessing (4-phenyl-1-piperazinyl)alkyl moieties at the 2-position were synthesized and tested for calcium antagonistic and calmodulin antagonistic activities. Antihypertensive effects in spontaneously hypertensive rats were also evaluated. In general, these compounds were rather weak calcium channel blockers, although, in contrast, many of them had moderate to potent calmodulin antagonistic activity, and 2-[3-(4-(4-fluorophenyl)-1-piperazinyl]propyl]-2H-1,4-benzothiazin-3(4H )-one derivatives 45, 74 and 75 showed potent antihypertensive effects.

1,4-benzothiazine derivatives, compositions containing them and method of use

1,4-Benzothiazine derivatives of the formula; STR1 wherein R1 and R2 independently stand for hydrogen, halogen, a lower alkyl group, a lower alkoxy group or trifluoromethyl group, or R1 and R2, taken together, f