139332-66-4

Basic information

• Product Name: 4-Nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole
• Synonyms: 4-NITRO-7-(1-PIPERAZINYL)-2,1,3-BENZOXADIAZOLE;4-NITRO-7-PIPERAZINO-2,1,3-BENZOXADIAZOLE;4-NITRO-7-PIPERAZINOBENZOFURAZAN;NBD-PZ;NBD-PZ(=4-NITRO-7-PIPERAZINO-2,1,3-BENZOXADIAZOLE)[FOR HPLC LABELING];nbd-pzforHPLClabeling;4-NITRO-7-PIPERAZINO-2,1,3-BENZOXADIAZOLE, NBD-PZ, FOR HPLC LABELING;NBD-PZ (=4-Nitro-7-piperazino-2,1,3-benzoxadiazole)
• CAS NO: 139332-66-4
• Molecular Formula: C₁₀H₁₁N₅O₃
• Molecular Weight: 249.23
• Product Categories: HPLC Labeling Reagents;Analytical Chemistry;Carboxyl Group Labeling Reagents for Fluorescence HPLC;Fluorescence Detection (HPLC Labeling Reagents)
• Mol File: 139332-66-4.mol
• Article Data: 17

Chemical Properties

• Melting Point: 208-212 °C
• Boiling Point: 475.679 °C at 760 mmHg
• Flash Point: 241.482 °C
• Appearance: /
• Density: 1.441 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: 2-8°C(protect from light)
• BRN: 7936339
• CAS DataBase Reference: 4-Nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole(139332-66-4)
• EPA Substance Registry System: 4-Nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole(139332-66-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 139332-66-4(Hazardous Substances Data)

Usage

Uses

Derivatizing agent for the determination of mono- & diisocyanates by LC and MS, UV or fluorescent detection .

InChI:InChI=1/C10H11N5O3/c16-15(17)8-2-1-7(9-10(8)13-18-12-9)14-5-3-11-4-6-14/h1-2,11H,3-6H2

Upstream product

• 110-85-0 piperazine 
• 10199-89-0 NBD chloride 
• 871508-91-7 4-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)piperazine-1-carboxylic acid tert butyl ester 
• 142-64-3 piperazine dihydrochloride 

Downstream Products

• 1269638-06-3 4-[4-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)piperazin-1-yl]-4-oxobutyric acid pentafluorophenyl ester 

Relevant articles and documents

A novel two-photon fluorescent probe for hydrogen sulfide in living cells using an acedan-NBD amine dyad based on FRET process with high selectivity and sensitivity

Two-photon imaging, due to its unique advantage to utilize near-infrared light as the excitation source, has emerged as an important tool for biomedical research. Herein, the first NBD amine based two-photon fluorescence probe L using a FRET strategy was developed for detecting H2S in vitro and in vivo. The probe L not only afforded high selectivity and sensitivity for the detection of H2S, but also displayed a linear response to H2S with a low detection limit of 24 nM. Furthermore, the living cell experiments indicated that L can be effective for the both exogenous and endogenous detection of H2S inside living cells by two-photon fluorescence imaging.

A GLUT1 inhibitor-based probe significantly ameliorates the sensitivity of tumor detection and diagnostic imaging

We report a non-antibody GLUT1 inhibitor probe NBDQ that is 30 times more sensitive than the traditional GLUT1 transportable tracer for cancer cell imaging and Warburg effect-based tumor detection. NBDQ reveals significant advantages in terms of tumor sel

Investigation of thiolysis of NBD amines for the development of H2S probes and evaluating the stability of NBD dyes

In order to evaluate the thiolysis of NBD (7-nitro-1,2,3-benzoxadiazole) amines for development of H2S probes, herein we investigated the reactivity and selectivity of a series of NBD amines for the first time. The piperazinyl- and piperidyl-ba

Triphenylamine derivative, preparation method thereof and application of triphenylamine derivative in double-channel fluorescence detection of hydrogen sulfide

The invention belongs to the technical field of fluorescent probes for H2S detection, and provides a triphenylamine derivative, a preparation method thereof, and application of the triphenylamine derivative in double-channel fluorescence detection of hydr

Benzooxaoxadiazole derivative as well as preparation method and application thereof

The invention discloses a benzooxaoxadiazole derivative as well as a preparation method and application thereof. The benzooxaoxadiazole derivative is prepared as follows: firstly, NBD-PZ is obtained by reaction between NBD-Cl and piperazine; then 4-nitro-7-(N-1'-acryloylpiperazine)-2,1,3-benzoxoxaoxadiazole is obtained by reaction between NBD-PZ and acryloyl chloride. The benzooxaoxadiazole derivative BGAS disclosed by the invention as a fluorescent probe has high selectivity for cysteine, can specifically detect the cysteine, particularly has a rapid detection effect on the cysteine in waterand simultaneously has relatively high sensitivity, thereby being applied to the detection of the cysteine in living cells.