1393441-94-5

Basic information

• Product Name: (E)-N¹-(6-fluoro-2-(4-methoxystyryl)quinolin-4-yl)-N²,N²-dimethylethane-1,2-diamine
• Synonyms: (E)-N¹-(6-fluoro-2-(4-methoxystyryl)quinolin-4-yl)-N²,N²-dimethylethane-1,2-diamine
• CAS NO: 1393441-94-5
• Molecular Weight: 365.45
• Mol File: 1393441-94-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-N¹-(6-fluoro-2-(4-methoxystyryl)quinolin-4-yl)-N²,N²-dimethylethane-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N¹-(6-fluoro-2-(4-methoxystyryl)quinolin-4-yl)-N²,N²-dimethylethane-1,2-diamine(1393441-94-5)
• EPA Substance Registry System: (E)-N¹-(6-fluoro-2-(4-methoxystyryl)quinolin-4-yl)-N²,N²-dimethylethane-1,2-diamine(1393441-94-5)

Safety Data

• Hazardous Substances Data: 1393441-94-5(Hazardous Substances Data)

Upstream product

• 371-40-4 4-fluoroaniline 
• 15912-68-2 6-fluoro-2-methylquinolin-4-ol 
• 1392200-88-2 N¹-(6-fluoro-2-methylquinolin-4-yl)-N²,N²-dimethylethane-1,2-diamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 18529-01-6 4-chloro-6-fluoro-2-methylquinoline 

Relevant articles and documents

ANTIMALARIAL COMPOUNDS

Antimalarial compounds of the formula: in which n is 1 or 2; X is C or N; R1 is a moiety comprising a secondary amine and a tertiary amine joined by a C2 to C4 alkyl chain; and R2 is CF3, F, or H, or an analog, combination, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof. Pharmaceutical compounds including the antimalarial compounds. Methods of treating or preventing malaria comprising administering an effective amount of the antimalarial compounds.

Design, synthesis and cytotoxicity of novel 2-arylvinyl-4- aminoquinoline derivatives

With an aim to develop promising anti-tumor agents, a novel series of 2-arylvinyl-4-aminoquinoline derivatives were designed, synthesized and evaluated for their cytotoxicity against H-460, HT-29, HepG2 and SGC-7901 cell lines in vitro. The pharmacological results indicated that most compounds were more potent than the positive controls, especially compounds 8, 14 and 16 with IC50 values ranging from 0.05 to 0.85 μM against all tested cell lines respectively, which were 5.7- to 112-fold better than Iressa. The most active compound 14 (IC50 values of 0.05, 0.25, 0.16, 0.68 μM), bearing 4-fluorostyryl at C-2 position and 3-(dimethylamino)-1-propylamino at C-4 position, showed great promise as a lead for the development of more effective quinoline analogues.