139357-01-0Relevant academic research and scientific papers
Near Absolute Regio-, Diastereo-, and Enantioselectivity in a Palladium Catalyzed Alkylation Using an Uncommon Chiral Auxiliary
Sjouken, Ronald,Ebens, Rijko,Kellogg, Richard M.
, p. 56 - 58 (1992)
Condensation of R-(+)-1-(2-chlorophenyl)-2,2-dimethyl-propan-1,3-diol (2) with a derivative (1) of 1-formylcyclohexene substituted in the 3-position with an acetoxy group proceeded with absolute stereospecificity at the acetal center.Catalytic alkylation of the ?-allyl complex obtained upon reaction with Pd with the anion of dimethylmalonate proceeded at the 3-position of the cyclohexyl ring with complete stereocontrol.
