139359-90-3Relevant academic research and scientific papers
Stereoisomerization of human constitutive androstane receptor agonist CITCO
Deschamps, Jeffrey R.,Diethelm-Varela, Benjamin,Imler, Gregory H.,Kumar, Anmol,Li, Yue,Lynch, Caitlin,MacKerell, Alexander D.,Xia, Menghang,Xue, Fengtian
, (2021)
CITCO (6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl) oxime) is a widely used agonist of the human constitutive androstane receptor (hCAR), a key hepatic xenobiotic sensor protein with emerging therapeutic indications.
CAR ACTIVATOR AGENTS FOR CYCLOPHOSPHAMIDE-BASED TREATMENTS OF CANCER
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Page/Page column 84; 85; 97, (2019/01/10)
The invention relates to selective small molecule human constitutive androstane receptor (hCAR) activators of Formula (I) or (II), pharmaceutical compositions thereof, and use thereof for the treatment of hematologic malignancies and other cancers. The sm
