82588-41-8

Basic information

• Product Name: 6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE
• Synonyms: BUTTPARK 2\01-46;6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE;6-(4-CHLORO-PHENYL)-IMIDAZO[2,1-B]THIAZOLE-5-CARBALDEHYDE;6-(4-CHLORO-PHENYL)-IMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE
• CAS NO: 82588-41-8
• Molecular Formula: C₁₂H₇ClN₂OS
• Molecular Weight: 262.71
• Mol File: 82588-41-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 192-195°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.48g/cm³
• Refractive Index: 1.728
• CAS DataBase Reference: 6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE(82588-41-8)
• EPA Substance Registry System: 6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE(82588-41-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 82588-41-8(Hazardous Substances Data)

Usage

Uses

6-(4-Chlorophenyl)imidazo[2,1-B][1,3]thiazole-5-carbaldehyde is an intermediate in the synthesis of CITCO (C433048) which is a cell-permeable imidazothiazole compound that acts a CAR agonist.

InChI:InChI=1/C12H7ClN2OS/c13-9-3-1-8(2-4-9)11-10(7-16)15-5-6-17-12(15)14-11/h1-7H

Upstream product

• 7025-30-1 6-(4'-chlorophenyl)imidazo<2,1-b>thiazole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 102410-33-3 Dimethylamino-acetic acid [1-[6-(4-chloro-phenyl)-imidazo[2,1-b]thiazol-5-yl]-meth-(E)-ylidene]-hydrazide 
• 139359-90-3 (E)-6-(4-chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde oxime 

Relevant articles and documents

Stereoisomerization of human constitutive androstane receptor agonist CITCO

CITCO (6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl) oxime) is a widely used agonist of the human constitutive androstane receptor (hCAR), a key hepatic xenobiotic sensor protein with emerging therapeutic indications.

DL5050, a Selective Agonist for the Human Constitutive Androstane Receptor

The constitutive androstane receptor (CAR) is a xenobiotic sensor governing the transcription of genes involved in drug disposition, energy homeostasis, and cell proliferation. However, currently available human CAR (hCAR) agonists are nonselective, which

CAR ACTIVATOR AGENTS FOR CYCLOPHOSPHAMIDE-BASED TREATMENTS OF CANCER

The invention relates to selective small molecule human constitutive androstane receptor (hCAR) activators of Formula (I) or (II), pharmaceutical compositions thereof, and use thereof for the treatment of hematologic malignancies and other cancers. The sm