139399-64-7

Usage

Uses

Used in Agricultural Industry:
6-Bromoquinolin-8-ol is used as a chemical intermediate for the preparation of 3,6-dibromo-8-quinolinol fungicides. These fungicides exhibit fungicidal activity against a range of fungal pathogens, including Aspergillus niger, Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride, and Mucor cirinelloides. The compound plays a crucial role in protecting crops from these harmful fungi, thereby ensuring better crop yield and quality.

Upstream product

• 103028-32-6 6-bromo-8-methoxy-quinoline 
• 57339-57-8 8-amino-6-bromoquinoline 
• 5467-64-1 2-acetamidophenyl acetate 
• 875-51-4 4-Bromo-2-nitroaniline 
• 59557-91-4 4-bromo-2-methoxyaniline 
• 91715-77-4 2-Acetamido-5-bromophenyl Acetate 
• 88-74-4 2-nitro-aniline 
• 68527-67-3 6-bromo-8-nitroquinoline 

Downstream Products

• 834906-36-4 2,2-Dimethyl-propionic acid 6-{(S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-quinolin-8-yl ester 
• 834906-32-0 1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol 
• 834906-34-2 6-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-quinolin-8-ol 
• 834906-29-5 2,2-Dimethyl-propionic acid 6-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-quinolin-8-yl ester 
• 834906-35-3 2,2-dimethyl-propionic acid 6-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-quinolin-8-yl ester 
• 834906-33-1 6-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-8-(tert-butyl-dimethyl-silanyloxy)-quinoline 

Relevant academic research and scientific papers

MACROCYCLIC COMPOUNDS

The present application discloses compounds of Formula (I). Such compounds, pharmaceutically acceptable salts and compositions thereof, are inhibitors of Mcl-1 proteins and are useful in treating diseases and conditions characterized by excessive cellular proliferation such as cancer.

HISTONE DEMETHYLASE INHIBITORS FOR TREATING CANCERS

The present disclosure provides a new series of 8-hydroxyquinoline derivatives/analogs that are potent KDM4 inhibitors with high activity and selectivity against KDM4 enzymes. Also disclosed are the pharmaceutical compositions comprising such 8-hydroxyqui

MCL-1 INHIBITORS AND METHODS OF USE THEREOF

Disclosed are Mcl-1 inhibitors, pharmaceutical compositions comprising the same and methods of using the same.

An extremely stable and orthogonal DNA base pair with a simplified three-carbon backbone

A nucleotide C3HQ with a minimal three-carbon backbone displays unprecedented pairing strength and orthogonality in a homopair C3HQ:C3HQ in the presence of one equivalent of Cu2+. The pairing stability in DNA ev

Preparation and Fungitoxicity of 3,6-Dichloro- and 3,6-Dibromo-8-Quinolinols

3,6-Dichloro- and 3,6-dibromo-8-quinolinols were prepared by direct halogenation of 8-nitroquinoline by N-halosuccinimide in acetic acid or by halogenation of the corresponding 6-halo-8-nitroquinoline prepared via a Skraup reaction.The nitro group was reduced to amino and the amine was hydrolyzed to the phenol in 70percent sulfuric acid at 220 deg C.The fungitoxicity of 3,6-dichloro- and 3,6-dibromo-8-quinolinols, as well as intermediates in their preparation, against Aspergillus niger, Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride, and Mucor cirinelloides was determined. 3,6-dichloro-8-quinolinol is the most fungitoxic analogue of this class of compounds observed to date. - Keywords. 3,6-dichloro-8-nitroquinoline; 3,6-dibromo-8-nitroquinoline; 8-amino-3,6-dichloroquinoline; 8-amino-3,6-dibromoquinoline; 3,6-dichloro-8-quinolinol; 3,6-dibromo-8-quinolinol; 1H NMR spectra.

Improved Syntheses of Some Monohloro- and Monobromo-8-quinolinols

Procedures were developed for the preparation of the 2-, 3-, 4-, and 6-monosubstituted chloro and bromo 8-quinolinols which afforded greater yields and/or reduced the number of steps in the preparation. 100 MHz 1H-NMR spetra for the 12 possible monochloro