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Usage

Uses

Used in Pharmaceutical Industry:
3-Bromoquinolin-8-amine is used as a reagent for the synthesis of various compounds with potential therapeutic applications. Its role in the development of new drugs makes it a valuable component in the pharmaceutical industry.
Used in Alzheimer's Disease Treatment:
3-Bromoquinolin-8-amine is used as a reagent for the synthesis of 3-(arylsulfonyl)-8-(piperidin-4-yl amino)quinoline derivatives, which are known as 5-HT6 receptor antagonists. These antagonists have the potential to treat Alzheimer's disease by modulating the serotonin receptor, which is implicated in the cognitive decline associated with the condition.
Used in Schizophrenia Treatment:
Similarly, 3-Bromoquinolin-8-amine is utilized in the synthesis of compounds that target the 5-HT6 receptor, which is also involved in the pathology of Schizophrenia. By developing antagonists for this receptor, it may be possible to alleviate some of the symptoms associated with this mental health disorder.
Used in Antimalarial Drug Synthesis:
3-Bromoquinolin-8-amine also serves as a reagent for the synthesis of certain 8-aminoquinolines, which are known for their antimalarial properties. These compounds can be used to develop new drugs to combat malaria, a disease that affects millions of people worldwide.

Upstream product

• 5341-07-1 8-nitro-3-bromoquinoline 
• 7647-01-0 hydrogenchloride 
• 607-35-2 8-nitroquinoline 
• 88-74-4 2-nitro-aniline 
• 5332-24-1 3-bromoquinoline 

Downstream Products

• 100125-12-0 3,8-dibromo-1,10-phenathroline 
• 139399-62-5 8-hydroxy-3-bromoquinoline 
• 103030-27-9 3-bromo-8-methoxyquinoline 

Relevant academic research and scientific papers

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms

A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8. The results indicated that substitut

PHENANTHROLINE PHOSPHONIC ACID DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

The present invention relates to a novel phenanthroline phosphonic acid compound and a pharmaceutical salt thereof, as well as an application of the compound and the pharmaceutical salt thereof as collagen prolyl hydroxylase inhibitors in the preparation of drugs for preventing or treating collagen prolyl-4-hydroxylase related disease.

5-Position-selective C-H trifluoromethylation of 8-aminoquinoline derivatives

We developed a copper-catalyzed 5-position-selective C-H trifluoromethylation of 8-aminoquinoline derivatives. The reaction proceeded with high functional group tolerance under mild conditions. In the case of quinolines with an amide, carbamate, urea, or sulfonamide group at the 8-position of quinoline moieties, a radical scavenger experiment indicated that the reaction proceeded via a radical pathway. The protecting group of an 8-amidoquinoline derivative could be removed by hydrolysis. On the other hand, the trifluoromethylation of 8-aminoquinolines was also promoted by other Lewis acids as well as a copper catalyst and proceeded even in the presence of a radical scavenger. These results indicated that the trifluoromethylation of 8-aminoquinolines proceeded via a Friedel-Crafts-type reaction. Interestingly, the copper salt works as either a catalyst for the formation of a CF3 radical or a Lewis acid to promote a Friedel-Crafts-type reaction, depending on the substrate.

QUINOLINE DERIVATIVES FOR DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE

A new class of quinoline compounds is useful for the detection and treatment of Alzheimer's disease and other neurodegenerative diseases such as amyloidoses and tauopathies. The compounds can be synthesized in radiolabeled form for use as imaging agents,

Synthesis and structure activity relationship of 3-(arylsulfonyl)-8- (piperidin-4-yl amino)quinoline derivatives as 5-HT6 receptor antagonists

As part of our efforts to develop better therapies for the treatment of cognitive impairment associated with Alzheimer's disease and Schizophrenia, we have focused our research towards 5-HT6 receptor (5-HT6R) in order to identify potent and selective ligands for this purpose. Herein, we report the synthesis, structure activity relationship and biological evaluation of a novel series of 3-(arylsulfonyl)-8- (piperidin-4-yl amino)quinoline derivatives, as 5-HT6 receptor (5-HT6R) antagonists. In this work, we have shown that moving from aryl sulfonamide platform to biaryl sulfone platform retains the 5-HT6.R affinity when tested in vitro in cell based reporter gene functional assay.

NITROGEN-CONTAINING HETEROARYL COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY

A compound of the formula (I): wherein Z4, Z5 and Z9 each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula: (wherein C ring is nitrogen-containing heteroaryl) has an inhibitory activity against integrase.

Improved Syntheses of Some Monohloro- and Monobromo-8-quinolinols

Procedures were developed for the preparation of the 2-, 3-, 4-, and 6-monosubstituted chloro and bromo 8-quinolinols which afforded greater yields and/or reduced the number of steps in the preparation. 100 MHz 1H-NMR spetra for the 12 possible monochloro