1394072-19-5

Basic information

• Product Name: 1-(3-(4-chlorophenyl)-4,5-dihydro-5-(4-nitrophenyl)pyrazol-1-yl)-2-(5-(4-methoxyphenyl)-1H-tetrazol-1-yl)ethanone
• Synonyms: 1-(3-(4-chlorophenyl)-4,5-dihydro-5-(4-nitrophenyl)pyrazol-1-yl)-2-(5-(4-methoxyphenyl)-1H-tetrazol-1-yl)ethanone
• CAS NO: 1394072-19-5
• Molecular Weight: 517.931
• Mol File: 1394072-19-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-(4-chlorophenyl)-4,5-dihydro-5-(4-nitrophenyl)pyrazol-1-yl)-2-(5-(4-methoxyphenyl)-1H-tetrazol-1-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-(4-chlorophenyl)-4,5-dihydro-5-(4-nitrophenyl)pyrazol-1-yl)-2-(5-(4-methoxyphenyl)-1H-tetrazol-1-yl)ethanone(1394072-19-5)
• EPA Substance Registry System: 1-(3-(4-chlorophenyl)-4,5-dihydro-5-(4-nitrophenyl)pyrazol-1-yl)-2-(5-(4-methoxyphenyl)-1H-tetrazol-1-yl)ethanone(1394072-19-5)

Safety Data

• Hazardous Substances Data: 1394072-19-5(Hazardous Substances Data)

Upstream product

• 874-90-8 4-methoxybenzonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 99-91-2 para-chloroacetophenone 
• 555-16-8 4-nitrobenzaldehdye 
• 1394071-86-3 2-[5-(4-methoxyphenyl)-1H-tetrazol-1-yl]acetohydrazide 
• 13736-61-3 (2E)-1-(4-chlorophenyl)-3-(4-nitrophenyl)prop-2-en-1-one 
• 3717-21-3 p-methoxyl benzaldoxime 

Relevant articles and documents

Synthesis and in vitro evaluation of novel tetrazole embedded 1,3,5-trisubstituted pyrazoline derivatives as Entamoeba histolytica growth inhibitors

A series of pyrazoline derivatives (1a-15a) was synthesized by cyclization of chalcones (1-15) with 2-[5-(4-methoxyphenyl)-1H-tetrazol-1-yl]acetohydrazide under basic conditions and were screened in vitro, to find out effect on the growth of HM1: IMSS strain of Entamoeba histolytica. The compounds 3a, 4a, 11a, 13a and 14a showed encouraging results with IC50 value in the range of 0.86-1.28 μM. However compound 13a showed most promising results with IC50 = 0.86 μM which is half of the metronidazole, the standard drug used for protozoal infection. Cell viability test in human hepatocellular carcinoma cell line (HepG2) revealed non-toxic nature of new synthesized compounds. Safety index calculations prevailed compound 13a as highly antiamoebic and least cytotoxic (S.I. = >116.28), almost twice than metronidazole.