1394290-74-4Relevant academic research and scientific papers
To alkine and 2,2-dichloro -1, 1, 1-trifluoroethane coupling reaction for preparing the fluorine-containing of alkynes
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Paragraph 0017-0021; 0024; 0028-0029; 0043-0045, (2017/01/09)
The invention relates to a method for preparing fluorine-containing alkyne employing coupled reaction of alkyne and 2,2-dichloro-1,1,1-trifluoroethane. Particularly, cuprous alkynyl or Z-substituent alkyne, 2,2-dichloro-1,1,1-trifluoroethane and copper po
Palladium-catalyzed decarboxylative trifluoroethylation of aryl alkynyl carboxylic acids
Hwang, Jinil,Park, Kyungho,Choe, Juseok,Min, Hongkeun,Song, Kwang Ho,Lee, Sunwoo
, p. 3267 - 3271 (2014/05/06)
A trifluoroethylation of alkynes through a palladium-catalyzed decarboxylative coupling reaction was developed. When alkynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(? 3-allyl)Cl]2/XantPhos and Cs2CO3 in N,N-dimethylformamide (DMF) at 80 °C for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group tolerance.
A facile parallel synthesis of trifluoroethyl-substituted alkynes
Liu, Cui-Bo,Meng, Wei,Li, Feng,Wang, Shuai,Nie, Jing,Ma, Jun-An
supporting information; experimental part, p. 6227 - 6230 (2012/08/14)
Trifluoroethylation made easy: The ease of execution of the reaction (see scheme), which runs under mild conditions and without the need for additional base or ligands, allows for the rapid parallel synthesis of a broad variety of trifluoroethylated alkynes. Both experimental and theoretical analyses indicate that the trifluoromethylcarbene could undergo concerted insertion into the Csp-H bond of the alkyne. Copyright
