139434-72-3Relevant articles and documents
The S,X-acetals in nucleoside chemistry. I. The synthesis of 2′- and 5′-O-methylthiomethylribonucleosides
Pechenov,Zavgorodny,Shvets,Miroshnikov
, p. 327 - 333 (2000)
Ribonucleoside 2′- and 5′-O-methylthiomethyl derivatives were synthesized from selectively protected nucleosides by the action of a dimethyl sulfoxide-acetic anhydride-acetic acid mixture.
An azidomethyl protective group in the synthesis of oligoribonucleotides by the phosphotriester method
Efimov,Aralov,Fedunin,Klykov,Chakhmakhcheva
scheme or table, p. 250 - 253 (2010/04/06)
A rapid and effective method of an automatic oligoribonucleotide synthesis alternative to the phosphoramidite one was developed. This method is based on the phosphotriester approach to internucleotide bond formation under intramolecular O-nucleophilic cat
Synthesis of RNA by the rapid phosphotriester method using azido-based 2'-O-protecting groups
Efimov,Aralov,Klykov,Chakhmakhcheva
experimental part, p. 846 - 865 (2010/08/22)
The azidomethyl and 2-(azidomethyl)benzoyl as 2'-OH protecting groups are reported for preparation of oligoribonucleotides by the phosphotriester solid-phase method using O-nucleophilic intramolecular catalysis. The procedures for the synthesis of the corresponding monomer synthons were developed and the usefulness of the application of 2'-O-azidomethyl and 2'-O-2-(azidomethyl) benzoyl groups was examined in the synthesis of different RNA fragments with a chain length of 15-22 nucleotides. The azidomethyl group was found to be more preferable for effective synthesis of oligoribonucleotides. Hybridization properties of RNAs toward their complementary oligonucleotides were examined before and after the removal of 2'-O-azidomethyl groups.
