139434-72-3

Basic information

• Product Name: Cytidine, N-benzoyl-2'-O-[(methylthio)methyl]-
• CAS NO: 139434-72-3
• Molecular Formula: C18H21N3O6S
• Molecular Weight: 407.447
• Mol File: 139434-72-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cytidine, N-benzoyl-2'-O-[(methylthio)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Cytidine, N-benzoyl-2'-O-[(methylthio)methyl]-(139434-72-3)
• EPA Substance Registry System: Cytidine, N-benzoyl-2'-O-[(methylthio)methyl]-(139434-72-3)

Safety Data

• Hazardous Substances Data: 139434-72-3(Hazardous Substances Data)

Upstream product

• 69304-43-4 1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]-N⁴-benzoylcytosine 
• 139434-68-7 N-benzoyl-3′,5′-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2′-O-[(methylthio)methyl]cytidine 

Relevant articles and documents

The S,X-acetals in nucleoside chemistry. I. The synthesis of 2′- and 5′-O-methylthiomethylribonucleosides

Ribonucleoside 2′- and 5′-O-methylthiomethyl derivatives were synthesized from selectively protected nucleosides by the action of a dimethyl sulfoxide-acetic anhydride-acetic acid mixture.

Synthesis of RNA by the rapid phosphotriester method using azido-based 2'-O-protecting groups

The azidomethyl and 2-(azidomethyl)benzoyl as 2'-OH protecting groups are reported for preparation of oligoribonucleotides by the phosphotriester solid-phase method using O-nucleophilic intramolecular catalysis. The procedures for the synthesis of the corresponding monomer synthons were developed and the usefulness of the application of 2'-O-azidomethyl and 2'-O-2-(azidomethyl) benzoyl groups was examined in the synthesis of different RNA fragments with a chain length of 15-22 nucleotides. The azidomethyl group was found to be more preferable for effective synthesis of oligoribonucleotides. Hybridization properties of RNAs toward their complementary oligonucleotides were examined before and after the removal of 2'-O-azidomethyl groups.