1394431-16-3

Basic information

• Product Name: lithium 6-fluoro-1-(phenylsulfonyl)-1H-indole-2-sulfinate
• Synonyms: lithium 6-fluoro-1-(phenylsulfonyl)-1H-indole-2-sulfinate
• CAS NO: 1394431-16-3
• Molecular Weight: 345.301
• Mol File: 1394431-16-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: lithium 6-fluoro-1-(phenylsulfonyl)-1H-indole-2-sulfinate(CAS DataBase Reference)
• NIST Chemistry Reference: lithium 6-fluoro-1-(phenylsulfonyl)-1H-indole-2-sulfinate(1394431-16-3)
• EPA Substance Registry System: lithium 6-fluoro-1-(phenylsulfonyl)-1H-indole-2-sulfinate(1394431-16-3)

Safety Data

• Hazardous Substances Data: 1394431-16-3(Hazardous Substances Data)

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 840474-96-6 6-fluoro-1-(phenylsulfonyl)-1H-indole 
• 399-51-9 6-fluoro-1H-indole 
• 348-37-8 6-fluoro-1H-indole-2-carboxylic acid ethyl ester 
• 658-27-5 m-fluorophenylhydrazine 

Downstream Products

• 1394431-17-4 6-fluoro-1-(phenylsulfonyl)-1H-indole-2-sulfonyl chloride 
• 1394431-18-5 N-(biphenyl-4-ylmethyl)-6-fluoro-1-(phenylsulfonyl)-1H-indole-2-sulfonamide 
• 1394431-19-6 N-(biphenyl-4-ylmethyl)-6-fluoro-1H-indole-2-sulfonamide 

Relevant articles and documents

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

Existing CB1 negative allosteric modulators (NAMs) fall into a limited range of structural classes. In spite of the theoretical potential of CB1 NAMs, published in vivo studies have generally not been able to demonstrate the expected therapeutically-relevant CB1-mediated effects. Thus, a greater range of molecular tools are required to allow definitive elucidation of the effects of CB1 allosteric modulation. In this study, we show a novel series of indole sulfonamides. Compounds 5e and 6c (ABD1075) had potencies of 4 and 3?nM respectively, and showed good oral exposure and CNS penetration, making them highly versatile tools for investigating the therapeutic potential of allosteric modulation of the cannabinoid system.