139446-83-6

Basic information

• Product Name: Nonanamide, N-[(3,4-dihydroxyphenyl)methyl]-
• CAS NO: 139446-83-6
• Molecular Formula: C16H25NO3
• Molecular Weight: 279.379
• Mol File: 139446-83-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Nonanamide, N-[(3,4-dihydroxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Nonanamide, N-[(3,4-dihydroxyphenyl)methyl]-(139446-83-6)
• EPA Substance Registry System: Nonanamide, N-[(3,4-dihydroxyphenyl)methyl]-(139446-83-6)

Safety Data

• Hazardous Substances Data: 139446-83-6(Hazardous Substances Data)

Upstream product

• 2444-46-4 Nonivamide 
• 764-85-2 Nonanoyl chloride 
• 16290-26-9 3,4-dihydroxybenzylamine hydrobromide 
• 37491-68-2 3,4-dihydroxybenzylamine 

Relevant articles and documents

Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b

Design approaches for inhibitors of protein-protein interactions are rare, but highly sought after. Here, we report that O-phosphorylation of simple derivatives of the natural products dihydrocapsaicin and N-vanillylnonanamide leads to inhibitors of the SH2 domain of the transcription factor STAT5b. The most potent molecule is obtained from dihydrocapsaicin in only three synthetic steps. It has submicromolar affinity for the SH2 domain of STAT5b (Ki = 0.34 μM), while displaying 35-fold selectivity over the highly homologous STAT5a (Ki = 13.0 μM). The corresponding pivaloyloxymethyl ester inhibits STAT5b with selectivity over STAT5a in human tumor cells. Importantly, it inhibits cell viability and induces apoptosis in human tumor cells in a STAT5-dependent manner. Our data validate O-phosphorylation of appropriately preselected natural products or natural product derivatives as a semirational design approach for small molecules that selectively inhibit phosphorylation-dependent protein-protein interaction domains in cultured human tumor cells.

Benzylamine acyl derivative and application thereof in preparing anti-inflammatory drugs

The invention provides a compound shown as formula A, or a pharmaceutically acceptable salt or solvate thereof, and an application thereof in preparing anti-inflammatory drugs. An experiment proves that the compound shown as formula A prepared in the inve

Ether bond cracking method of phenylalkyl ether

The invention discloses an ether bond cracking method of phenylalkyl ether. The method comprises the following steps: performing ether bond breaking reaction on phenylalkyl ether at -20 to reflux temperature in the presence of aluminium triiodide and dimethyl sulfoxide, thereby generating phenol and derivatives thereof. The method disclosed by the invention is mild in condition, simple and convenient for operation, high in yield, and extensive in applicable phenylalkyl ether range.