90843-19-9

Upstream product

• 43192-31-0 2-bromo-4-methoxybenzaldehyde 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 139469-06-0 1-bromo-5-dimethoxy-2-vinylbenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 197015-32-0 4-methoxy-2-trifluoromethanesulfonyloxybenzaldehyde 

Downstream Products

• 1223004-89-4 C₁₇H₁₇NO₂ 
• 1042031-55-9 2-(4-methoxyphenyl)-1(2H)-6-methoxyisoquinolinone 
• 197015-33-1 1-Cyclopropylidenemethyl-4-methoxy-2-vinyl-benzene 

Relevant academic research and scientific papers

Palladium-Catalyzed Tandem Hydrocarbonylative Lactamization and Cycloaddition Reaction for the Construction of Bridged Polycyclic Lactams

The intramolecular hydroaminocarbonylation of alkenes is a compelling tool to rapidly access lactam, a privileged motif ubiquitous in natural products, pharmaceuticals, and agrochemicals. However, selective carbonylation to bridged polycyclic lactams with a lactam nitrogen at a bridgehead position is less explored. We herein report a modular palladium-catalyzed approach to perform a tandem hydrocarbonylative lactamization/Diels-Alder cycloaddition reaction with 2-vinyl aryl aldimines, alkenes, and CO, which offers convenient access to furnish the bridged polycyclic lactams in high yields with high selectivities.

Carbonylative cycloaddition between two different alkenes enabled by reactive directing groups: Expedited construction of bridged polycyclic skeletons

A novel palladium-catalyzed highly selective hydrocarbonylative cycloaddition reaction with two different alkenes in the presence of CO enabled by a reactive directing-group is developed, which offers efficient and convenient access to lactone-containing bridged polycyclic compounds in high yield with high chemo- and stereoselectivities.

Stereoselective Convergent Synthesis of Tetrahydro-5 H-benzo[c]fluorene via Nine-Membered Ring-Closing Metathesis and Transannular Acid-Mediated Cyclization/Nucleophilic Addition

The diene methyl ethers or acetates, constructed from the Li-Br exchange/addition reactions of 2-vinylbenzaldehydes and 2-(but-3-en-1-yl)bromoarenes followed by etherification or acetylation of the corresponding alcohols, smoothly underwent the ring-closi

AgOTf-catalyzed sequential synthesis of 4-isoquinolones: Via oxidative ring opening of aziridines and aza-Michael addition

An efficient AgOTf-catalyzed sequential reaction involving the oxidative ring-opening of aziridines by DMSO and aza-Michael addition has been developed. A series of 2,3-dihydro-4(1H)-isoquinolones were afforded in moderate to good yields by the formation of one new CO bond and one new C-N bond. The features of this sequential reaction include high bonding efficiency, use of a catalytic amount of catalysts, a broad substrate scope and mild conditions. This methodology provides a good choice for constructing the libraries of 2,3-dihydro-4(1H)-isoquinolones.

2-PHENYL INDENE DERIVATIVES USEFUL AS ESTROGEN RECEPTOR LIGANDS

The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity. Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined in the specification, and wherein either the bond between the C1and C2 carbon atoms is a double bond or the bond between the C2 and C3 carbon atoms is a double bond, R2 being absent when the bond between the C1 and C2 carbon atoms is a double bond.

A Novel Palladium-Mediated Cascade Reaction Triggered by Strain Release of the Cyclobutane System. A New General Route to Benzo- and Naphthohydrindans

A novel palladium-mediated cascade reaction was reported.By this procedure, the olefinic cyclobutanols 17, 24, and 31; 41; 37; and 45 afforded the benzo- and naphthohydrindans (46-49, 50-53, 54-57, and 58-61) respectively in one operation in the ratios depending on the mediators and solvents employed.This provides a novel and efficient synthesis of biologically important A-nor and C11-alkylated steroids.

Synthesis of benzimidazo[2,1-a]isoquinolines and 5,6-dihydrobenzimidazo[2,1-a]isoquinolines

The formation of substituted benzimidazo[2,1-a]isoquinolines by the palladium-catalyzed intramolecular cyclization of 2-[2-(2-trimethylsilyl-ethynyl)phenyl]-1H-benzimidazole is described. 5,6-Dihydrobenzimidazo[2,1-a]isoquinolines were formed directly dur