1394818-63-3

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 1394818-62-2 (S)-2-((S)-(4-methoxybenzyloxy)(phenyl)methyl)oxirane 
• 1394818-61-1 (2S,3S)-2,3-dihydroxy-3-phenylpropyl 4-methylbenzenesulfonate 
• 2746-25-0 p-Methoxybenzyl bromide 
• 104-54-1 3-Phenylpropenol 

Downstream Products

• 1394818-64-4 (1R,2R)-ethyl 2-((R)-hydroxy(phenyl)methyl)cyclopropanecarboxylate 
• 1394818-66-6 (1R,2R)-2-((S)-azido(phenyl)methyl)cyclopropanecarboxylic acid 
• 499982-30-8 (2S,1'R,2'R)-2-(carboxycyclopropyl)glycine 
• 1394818-65-5 (1R,2R)-ethyl 2-((S)-azido(phenyl)methyl)cyclopropanecarboxylate 

Relevant academic research and scientific papers

Enantio- and diastereocontrolled conversion of chiral epoxides to trans-cyclopropane carboxylates: Application to the synthesis of cascarillic acid, grenadamide and l-(-)-CCG-II

An efficient high yielding improved method for the enantio- and diastereoselective cyclopropanation of chiral epoxides using triethylphosphonoacetate and base (Wadsworth-Emmons cyclopropanation) is reported. The utility of this protocol is illustrated by concise and practical synthesis of cascarillic acid, grenadamide and L-(-)-CCG-II, a cyclopropane containing natural products.