1394820-98-4

Basic information

• Product Name: 4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol
• Synonyms: 4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol
• CAS NO: 1394820-98-4
• Molecular Formula: C₁₅H₉FN₂O₄
• Molecular Weight: 300.2413632
• Mol File: 1394820-98-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 467.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.487±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.46±0.40(Predicted)
• CAS DataBase Reference: 4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol(1394820-98-4)
• EPA Substance Registry System: 4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol(1394820-98-4)

Safety Data

• Hazardous Substances Data: 1394820-98-4(Hazardous Substances Data)

Usage

General Description

4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol is a chemical compound with the molecular formula C16H9FN2O4. It is a quinoline derivative that contains a fluoro and nitro group attached to a phenoxy ring. 4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol has potential applications in pharmaceuticals and materials science due to its unique structure and properties. It may be used in the synthesis of various organic compounds and may also possess biological activity that could be investigated for potential pharmacological uses. However, more research is needed to fully understand its potential applications and effects.

Upstream product

• 1484-26-0 3-(benzyloxy)aniline 
• 749922-34-7 7-(benzyloxy)quinolin-4-ol 
• 178984-56-0 7-(benzyloxy)-4-chloroquinoline 
• 909345-85-3 5-((3-(benzyloxy)phenylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 403-19-0 2-fluoro-4-nitrophenol 
• 1039046-51-9 4-(2-fluoro-4-nitrophenoxy)-7-methoxyquinoline 
• 68500-37-8 4-chloro-7-methoxyquinoline 

Downstream Products

• 1394820-99-5 1-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropan-2-ol 
• 1394820-91-7 N-(3-fluoro-4-((7-((1-hydroxy-2-methylpropan-2-yl)oxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1394821-11-4 methyl 2-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropanoate 
• 1394821-12-5 2-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropan-1-ol 
• 1394821-13-6 2-((4-(4-amino-2-fluorophenoxy)quinolin-7-yl)oxy)-2-methylpropan-1-ol 
• 1394821-01-2 4-(4-amino-2-fluorophenoxy)quinolin-7-ol 

Relevant articles and documents

Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2

New N-substituted-3-phenyl-1,6-naphthyridinone derivatives are designed and synthesized, based on structural modification of our previously reported compound 3. Extensive enzyme-based SAR studies and PK evaluation led to the discovery of compound 4r, with

Discovery of N-[4-(Quinolin-4-yloxy)phenyl]benzenesulfonamides as Novel AXL Kinase Inhibitors

The overexpression of AXL kinase has been described in many types of cancer. Due to its role in proliferation, survival, migration, and resistance, AXL represents a promising target in the treatment of the disease. In this study we present a novel compound family that successfully targets the AXL kinase. Through optimization and detailed SAR studies we developed low nanomolar inhibitors, and after further biological characterization we identified a potent AXL kinase inhibitor with favorable pharmacokinetic profile. The antitumor activity was determined in xenograft models, and the lead compounds reduced the tumor size by 40% with no observed toxicity as well as lung metastasis formation by 66% when compared to vehicle control.