749922-34-7

Basic information

• Product Name: 7-BENZYLOXY-4-HYDROXY-QUINOLINE
• Synonyms: 7-BENZYLOXY-4-HYDROXY-QUINOLINE;7-(Benzyloxy)quinolin-4-ol;7-(Benzyloxy)-4-hydroxyquinoline, 7-(Benzyloxy)-4-hydroxy-1-azanaphthalene
• CAS NO: 749922-34-7
• Molecular Formula: C₁₆H₁₃NO₂
• Molecular Weight: 251.28
• Mol File: 749922-34-7.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 455.8 °C at 760 mmHg
• Flash Point: 229.5 °C
• Appearance: /
• Density: 1.256 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.12±0.40(Predicted)
• CAS DataBase Reference: 7-BENZYLOXY-4-HYDROXY-QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BENZYLOXY-4-HYDROXY-QUINOLINE(749922-34-7)
• EPA Substance Registry System: 7-BENZYLOXY-4-HYDROXY-QUINOLINE(749922-34-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 749922-34-7(Hazardous Substances Data)

Usage

General Description

7-Benzyloxy-4-hydroxy-quinoline is a chemical compound with the molecular formula C17H13NO2. It is a quinoline derivative that contains a benzyloxy group and a hydroxyl group. 7-BENZYLOXY-4-HYDROXY-QUINOLINE is often used in organic and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and biologically active compounds. It has shown potential as an antimalarial and antibacterial agent, and its structure and properties make it a promising candidate for drug development. Additionally, 7-benzyloxy-4-hydroxy-quinoline has also been studied for its potential antioxidant and anti-inflammatory properties, making it a versatile and valuable compound for research and development in the field of pharmaceuticals.

Upstream product

• 749922-33-6 5-{[(3-benzyloxy)phenylimino]methyl}-2,2-dimethyl-[1,3]-dioxane-4,6-dione 
• 1484-26-0 3-(benzyloxy)aniline 
• 909345-85-3 5-((3-(benzyloxy)phenylamino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 178984-56-0 7-(benzyloxy)-4-chloroquinoline 
• 1221443-46-4 N-(3-fluoro-4-(7-hydroxyquinolin-4-yloxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1394820-97-3 7-benzyloxy-4-(2-fluoro-4-nitrophenoxy)quinoline 
• 1394820-98-4 4-(2-fluoro-4-nitrophenoxy)quinolin-7-ol 
• 1394820-99-5 1-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropan-2-ol 
• 1394820-70-2 (R)-N-(3-fluoro-4-((7-(2-hydroxypropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1394821-01-2 4-(4-amino-2-fluorophenoxy)quinolin-7-ol 
• 1394820-83-7 N-(4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1394821-02-3 7-(benzyloxy)-4-(4-nitrophenoxy)quinoline 
• 1394821-03-4 4-(4-nitrophenoxy)quinolin-7-ol 
• 1394821-04-5 2-methyl-1-((4-(4-nitrophenoxy)quinolin-7-yl)oxy)propan-2-ol 
• 1394821-05-6 1-((4-(4-aminophenoxy)quinolin-7-yl)oxy)-2-methylpropan-2-ol 
• 1394820-85-9 N-(4-((7-(2-hydroxyethoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1394821-06-7 2-((4-(4-nitrophenoxy)quinolin-7-yl)oxy)ethanol 

Relevant articles and documents

7- OR 8-HYDROXY-ISOQUINOLINE AND 7- OR 8-HYDROXY-QUINOLINE DERIVATIVES AS ALPHA-1 -ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1 -ANTITRYPSIN DEFICIENCY (AATD)

7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD).

Quinoline derivatives (by machine translation)

A compound represented by general formula (I) (I) has a strong Axl inhibiting activity by introducing a distinctive bicyclic structure in which a saturated carbocyclic ring is fused to a pyridone ring, and thus may be used as a therapeutic agent for Axl related diseases such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, cancer such as glioma, kidney disease, immune system disease, and circulatory system disease.

SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted quinoline compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.