1394865-84-9Relevant academic research and scientific papers
Synthesis and anticancer evaluation of novel 10-methoxycamptothecin derivatives
Zhu, Meixuan,Jing, Lijia,Wang, Shaoming,Zhang, Sheng,Wang, Yang
, p. 932 - 934 (2015)
As part of our continuing search for potential anticancer drug candidates, we have synthesized four 10-methoxycamptothecin derivatives. The compounds were synthesized by facile procedures and characterized by 1H NMR, 13C NMR and mass spectra study. The synthesized compounds were examined for their cytotoxic effect on a panel of five human cancer cell lines. Three out of five compounds were found to exhibit moderate anticarcinogenic activities in all cell lines. The result of the present investigation encourage us to develop more other related compounds and to screen them for a wide range of biological activity.
DERIVATE, PREPARATION METHOD AND USE OF 10-METHOXYCAMPTOTHECINE
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Paragraph 0042-0044, (2014/07/22)
Provided is a 10-methoxycamptothecine derivate of formula (1), wherein R is selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, aryl substituted C1-6 alkyl, phosphate substituted C1-6 alkyl, amino-substituted C1-6 alkyl, carboxyl substituted C1-6 alkyl, hydroxyl substituted C1-6 alkyl, and amide- substituted C1-6 alkyl; R1 is selected from hydrogen and t-butoxycarbonyl substituted amino. Also provided in the present invention are the preparation method of the derivate and the use thereof in anti-tumor drug preparation.
