139503-12-1

Basic information

• Product Name: 4-(3,5-DIFLUOROPHENYL)-TETRAHYDRO-2H-PYRAN-4-OL
• Synonyms: 4-(3,5-DIFLUOROPHENYL)-TETRAHYDRO-2H-PYRAN-4-OL
• CAS NO: 139503-12-1
• Molecular Formula: C₁₁H₁₂F₂O₂
• Molecular Weight: 214.21
• Mol File: 139503-12-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 327.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.294±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.19±0.20(Predicted)
• CAS DataBase Reference: 4-(3,5-DIFLUOROPHENYL)-TETRAHYDRO-2H-PYRAN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,5-DIFLUOROPHENYL)-TETRAHYDRO-2H-PYRAN-4-OL(139503-12-1)
• EPA Substance Registry System: 4-(3,5-DIFLUOROPHENYL)-TETRAHYDRO-2H-PYRAN-4-OL(139503-12-1)

Safety Data

• Hazardous Substances Data: 139503-12-1(Hazardous Substances Data)

Usage

Description

4-(3,5-DIFLUOROPHENYL)-TETRAHYDRO-2H-PYRAN-4-OL, also known as 2-(3,5-difluorophenyl)tetrahydro-4H-pyran-4-ol, is a heterocyclic compound belonging to the class of pyrans. It features a six-membered ring with five carbon atoms and one oxygen atom, and is a derivative of tetrahydropyran with a tetrahydro-2H-pyran-4-ol core substituted by a 3,5-difluorophenyl group. Its unique chemical structure and properties make it a valuable compound for pharmaceutical and chemical research, including drug synthesis and medicinal chemistry.

Uses

Used in Pharmaceutical Research:
4-(3,5-DIFLUOROPHENYL)-TETRAHYDRO-2H-PYRAN-4-OL is used as a key intermediate in the synthesis of various pharmaceutical compounds due to its unique structure and potential biological activity.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-(3,5-DIFLUOROPHENYL)-TETRAHYDRO-2H-PYRAN-4-OL serves as a building block for the development of new drugs, contributing to the discovery of novel therapeutic agents.
Used in Chemical Research:
4-(3,5-DIFLUOROPHENYL)-TETRAHYDRO-2H-PYRAN-4-OL is utilized in chemical research to explore its properties and potential applications, furthering the understanding of its role in various chemical reactions and processes.

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 62351-47-7 3,5-difluorophenylmagnesium bromide 
• 461-96-1 3,5-difluorobromobenzene 

Downstream Products

• 1395281-88-5 4-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)tetrahydro-2H-pyran-4-ol 
• 1395281-91-0 methyl 6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinate 
• 1395281-94-3 6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropicolinic acid 
• 1395281-48-7 4-(3,5-difluorophenyl)-3,6-dihydro-2H-pyran 
• 139503-13-2 4-(3,5-difluorophenyl)-4-methoxy-3,4,5,6-tetrahydro-2H-pyran 
• 1395281-51-2 4-(3,5-difluorophenyl)tetrahydro-2H-pyran 

Relevant articles and documents

PYRIDINEAMINE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

The present disclosure describes pyridineamine compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer, immune disorders and other diseases. Formula (I).

ARYL-SUBSTITUTED FUSED BICYCLIC PYRIDAZINE COMPOUNDS

The present invention provides a compound of formula (I) as described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by PIM kinase using the compounds of Formula (I), and pharmaceutical compositions comprising such compounds.

NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS

The present invention provides a compound of formula (A): I as described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating a disease or condition mediated by PIM kinase using the compounds of Formula I, and pharmaceutical compositions comprising such compounds.