139503-13-2

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 139503-12-1 4-(3,5-difluorophenyl)tetrahydro-2H-pyran-4-ol 
• 74-88-4 methyl iodide 
• 62351-47-7 3,5-difluorophenylmagnesium bromide 

Downstream Products

• 133739-16-9 6-[(3-fluoro-5-[4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl]phenoxy)methyl]quinoline 
• 139502-85-5 4-[5-fluoro-3-(4-methyl-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-7-ylthio)phenyl]-4-methoxytetrahydropyran 
• 153581-71-6 4-[5-fluoro-3-(4-hydroxymethylbenzyloxy)phenyl]-4-methoxytetrahydropyran 
• 143128-22-7 4-[5-fluoro-3-(4-phenoxyphenoxy)phenyl]-4-methoxytetrahydropyran 

Relevant academic research and scientific papers

PYRIDINEAMINE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

The present disclosure describes pyridineamine compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer, immune disorders and other diseases. Formula (I).

BENZOXAZINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENES

The invention concerns a bicyclic heterocyclic compound of the formula I wherein Q is an optionally substituted 10-membered bicyclic heterocyclic moiety containing 1 or 2 N's and a further O or S heteroatom; A1 is a direct link to X1 or (1-3C)alkylene; X1 is oxy, thio, sulphinyl, sulphonyl or imino; Ar is optionally substituted phenylene or pyridylene; R1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; and R2 and R3 together form a group of the formula -A2-X2-A3- which, together with the carbon atom to which A2 and A3 are attached, defines a ring having 5 to 7 ring atoms, wherein each of A2 and A3 is (1-3C)alkylene and X2 is oxy, thio, sulphinyl or sulphonyl; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase

ARYL DERIVATIVES

The invention concerns an aryl derivative of the formula I, wherein Ar1 is optionally substituted phenyl, naphthyl or a heterocyclic moiety, and X1 is oxy, thio, sulphinyl, sulphonyl, difluoromethylene, imino, (1-4C)alkylimino or optionally substituted (1-4C) alkylene, or X1 is a group of the formula wherein X4 is oxy, thio, sulphinyl, sulphonyl or carbonyl and each R is hydrogen, methyl or ethyl each of Ar2 and Ar3 is optionally substituted phenylene X2 is oxy, thio, sulphinyl or sulphonyl R1 is (1-4C)alkyl and R2 and R3 together form a group of the formula A1 X3 A2 which together with the carbon atom to which A1 and A2 are attached define a ring having 5 to 7 ring atoms, wherein each of A1 and A2 is (1-3C) alkylene and X3 is oxy, thio, sulphinyl or sulphonyl which compounds are inhibitors of 5-lipoxygenase and are useful in the treatment of inflammatory or allergic disease