1395050-38-0Relevant articles and documents
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)
Lin, Wen-Hsing,Hsu, John T.-A.,Hsieh, Shu-Yi,Chen, Chiung-Tong,Song, Jen-Shin,Yen, Shih-Chieh,Hsu, Tsu,Lu, Cheng-Tai,Chen, Chun-Hwa,Chou, Ling-Hui,Yang, Yung-Ning,Chiu, Ching-Hui,Chen, Ching-Ping,Tseng, Ya-Ju,Yen, Kuei-Jung,Yeh, Ching-Fang,Chao, Yu-Sheng,Yeh, Teng-Kuang,Jiaang, Weir-Torn
, p. 2856 - 2867 (2013/06/27)
Preclinical investigations and early clinical trials suggest that FLT3 inhibitors are a viable therapy for acute myeloid leukemia. However, early clinical data have been underwhelming due to incomplete inhibition of FLT3. We have developed 3-phenyl-1H-5-p