78583-83-2

Basic information

• Product Name: 5-(4-NITROPHENYL)-2H-PYRAZOL-3-YLAMINE
• Synonyms: 5-(4-NITROPHENYL)-2H-PYRAZOL-3-YLAMINE;5-(4-NITRO-PHENYL)-1(2)H-PYRAZOL-3-YLAMINE;5-(4-NITROPHENYL)-1H-PYRAZOL-3-AMINE;5-(4-NITROPHENYL)-2H-PYRAZOL-3-YLAMINE 5-(4-NITROPHENYL)-1H-PYRAZOL-3-AMINE 5-(4-NITRO-PHENYL)-2H-PYRAZOL-3-YLAMINE;3-(4-nitrophenyl)-1H-pyrazol-5;5-(4-Nitrophenyl)-2H-pyrazol-3-ylamine ,99%;3-Amino-5-(4-nitrophenyl)-1H-pyrazole;5-(4-Nitrophenyl)-2H-pyrazole-3yl-amine
• CAS NO: 78583-83-2
• Molecular Formula: C₉H₈N₄O₂
• Molecular Weight: 204.19
• Product Categories: pharmacetical;API intermediates
• Mol File: 78583-83-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 255-259°C
• Boiling Point: 530 °C at 760 mmHg
• Flash Point: 274.4 °C
• Appearance: /
• Density: 1.454 g/cm³
• CAS DataBase Reference: 5-(4-NITROPHENYL)-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-NITROPHENYL)-2H-PYRAZOL-3-YLAMINE(78583-83-2)
• EPA Substance Registry System: 5-(4-NITROPHENYL)-2H-PYRAZOL-3-YLAMINE(78583-83-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 78583-83-2(Hazardous Substances Data)

Usage

Chemical Properties

Brown powder

Upstream product

• 78583-88-7 (E)-3-Chloro-3-(4-nitro-phenyl)-acrylonitrile 
• 3383-43-5 (4-Nitrobenzoyl)acetonitrile 

Downstream Products

• 149247-06-3 2-(4-Nitro-phenyl)-4H-pyrazolo[1,5-a]pyrimidin-7-one 
• 1395050-51-7 N₁-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino]phenyl-1H-5-pyrazolyl)-4-[(4-methylpiperazino)methyl]benzamide 
• 1395050-49-3 N-(3-(4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino]phenyl)-1H-5-pyrazolyl)-4-(2-(tetrahydro-1H-1-pyrrolyl)ethoxy)benzamide 
• 1391621-85-4 C₂₂H₂₅N₅O₂ 
• 1395050-47-1 N-[3-(4-{[(5-(tert-butyl)-1,2-oxazol-3-yl)carbamoyl]amino}phenyl)-1H-pyrazol-5-yl]-4-[3-(pyrrolidin-1-yl)propoxy]benzamide 
• 1395050-45-9 N₁-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino]phenyl-1H-5-pyrazolyl)-4-(4-methylpiperazino)benzamide 
• 1575718-04-5 3,4-di(4-nitrophenyl)-1H-benzo[h]pyrazolo[3,4-b]quinolin-5,6-dione 
• 1575718-02-3 4-(4-chlorophenyl)-3-(4-nitrophenyl)-1H-benzo[h]pyrazolo[3,4-b]quinolin-5,6-dione 
• 1575717-99-5 4-(4-methoxyphenyl)-3-(4-nitrophenyl)-1H-benzo[h]pyrazolo[3,4-b]quinolin-5,6-dione 
• 1395051-01-0 N-[4-(5-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinyl]amino-1H-3-pyrazolyl)phenyl]-N'-phenylurea 
• 1433716-62-1 N-(3-{4-[(cyclopropylaminocarbonyl)amino]phenyl}-1H-5-pyrazolyl)-4-(4-methylpiperazino)benzamide 
• 1395050-39-1 N-(3-{4-[(ethylaminocarbonyl)amino]phenyl}-1H-5-pyrazolyl)-4-(4-methylpiperazino)benzamide 
• 1395050-38-0 N-(3-{4-[(anilinocarbonyl)amino]phenyl}-1H-5-pyrazolyl)-4-(4-methylpiperazino)benzamide 

Relevant articles and documents

Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups.

New synthesis of 3-aryl-5-amino-1H-pyrazoles

A new efficient procedure has been proposed for the synthesis of 3-aryl-5-amino-1H-pyrazoles by reaction of α-chloro-β- arylacrylonitriles with hydrazine hydrate.