1327167-35-0

Basic information

• Product Name: N-[3-(4-aminophenyl)-1H-5-pyrazolyl]-4-(4-methylpiperazino)benzamide
• Synonyms: N-[3-(4-aminophenyl)-1H-5-pyrazolyl]-4-(4-methylpiperazino)benzamide
• CAS NO: 1327167-35-0
• Molecular Weight: 376.461
• Mol File: 1327167-35-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-[3-(4-aminophenyl)-1H-5-pyrazolyl]-4-(4-methylpiperazino)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(4-aminophenyl)-1H-5-pyrazolyl]-4-(4-methylpiperazino)benzamide(1327167-35-0)
• EPA Substance Registry System: N-[3-(4-aminophenyl)-1H-5-pyrazolyl]-4-(4-methylpiperazino)benzamide(1327167-35-0)

Safety Data

• Hazardous Substances Data: 1327167-35-0(Hazardous Substances Data)

Upstream product

• 78583-83-2 5-amino-3-(4-nitrophenyl)-1H-pyrazole 
• 401495-67-8 4-(4-methylpiperazin-4-ium-1-yl)benzoyl chloride 

Downstream Products

• 1391621-56-9 benzyl-N-[4-(5-[4-(4-methylpiperazino)benzoyl]amino-1H-3-pyrazolyl)phenyl]carbamate 
• 1391621-57-0 phenyl-N-[4-(5-[4-(4-methylpiperazino)benzoyl]amino-1H-3-pyrazolyl)phenyl]carbamate 
• 1395050-45-9 N₁-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino]phenyl-1H-5-pyrazolyl)-4-(4-methylpiperazino)benzamide 
• 1433716-62-1 N-(3-{4-[(cyclopropylaminocarbonyl)amino]phenyl}-1H-5-pyrazolyl)-4-(4-methylpiperazino)benzamide 
• 1395050-39-1 N-(3-{4-[(ethylaminocarbonyl)amino]phenyl}-1H-5-pyrazolyl)-4-(4-methylpiperazino)benzamide 
• 1395050-38-0 N-(3-{4-[(anilinocarbonyl)amino]phenyl}-1H-5-pyrazolyl)-4-(4-methylpiperazino)benzamide 

Relevant articles and documents

Pyrazolylamine Derivatives Reveal the Conformational Switching between Type i and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK)

Most anaplastic lymphoma kinase (ALK) inhibitors adopt a type I binding mode, but only limited type II ALK structural studies are available. Herein, we present the structure of ALK in complex with N1-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino

3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)

A new class of FLT3 inhibitors has been identified based on the 3-phenyl-1H-5-pyrazolylamine scaffold. The structure-activity relationships led to the discovery of two carbamate series, and some potent compounds within these two series exhibited better gr

Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)

Preclinical investigations and early clinical trial studies suggest that FLT3 inhibitors offer a viable therapy for acute myeloid leukemia. However, early clinical data for direct FLT3 inhibitors provided only modest results because of the failure to fully inhibit FLT3. We have designed and synthesized a novel class of 3-phenyl-1H-5-pyrazolylamine-derived compounds as FLT3 inhibitors which exhibit potent FLT3 inhibition and high selectivity toward different receptor tyrosine kinases. The structure-activity relationships led to the discovery of two series of FLT3 inhibitors, and some potent compounds within these two series exhibited comparable potency to FLT3 inhibitors sorafenib (3) and ABT-869 (4) in both wt-FLT3 enzyme inhibition and FLT3-ITD inhibition on cell growth (MOLM-13 and MV4;11 cells). In particular, the selected compound 12a exhibited the ability to regress tumors in mouse xenograft models using MOLM-13 and MV4;11 cells.