139554-72-6

Usage

Chemical Properties

White Solid

InChI:InChI=1/C16H22N4O4S/c21-12(17-7-8-20-13(22)5-6-14(20)23)4-2-1-3-11-15-10(9-25-11)18-16(24)19-15/h5-6,10-11,15H,1-4,7-9H2,(H,17,21)(H2,18,19,24)/t10?,11-,15?/m0/s1

Upstream product

• 58-85-5 biotin 
• 146474-00-2 N-(2-aminoethyl)maleimide trifluoroacetic acid salt 
• 35013-72-0 biotin N-Hydroxysuccinimide ester 
• 125923-10-6 1-(2-aminoethyl)-1H-pyrrole-2,5-dione 
• 215654-55-0 C₁₁H₁₈N₂O₅ 
• 134272-63-2 N-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-carbamic acid tert-butyl ester 
• 146474-00-2 N-(2-aminoethyl)maleimide trifluoroacetate 

Relevant academic research and scientific papers

Sequential DNA-Encoded Building Block Fusion for the Construction of Polysubstituted Pyrazoline Core Libraries

The construction of chemical libraries containing polysubstituted pyrazoline scaffolds is highly desirable for the discovery of novel chemical ligands for biological targets. Herein, we report a sequential DNA-encoded synthesis strategy for polysubstitute

The versatility of N-alkyl-methoxyamine bi-functional linkers for the preparation of glycoconjugates

The application of N-glycosyl-N-alkyl-methoxyamine bi-functional linkers for the synthesis of a variety of glycoconjugates is described. The linker contains a specific functional group, such as an amine, azide, thiol, or carboxylic acid, which can be used for conjugation methodologies that include amide ligation, sulfonylation, copper-mediated Huisgen cycloaddition or thiol-maleimide coupling. In this way, glycoconjugates equipped with biotin, a fluorescent reporter, or a protein were efficiently synthesised, thus demonstrating the versatility of this type of oxyamine linker for the construction of glycoconjugate probes.

ANTIBODY CONJUGATES AND METHODS OF MAKING THE ANTIBODY CONJUGATES

Described herein are antibody conjugates and methods of making antibody conjugates.