1395896-87-3

Basic information

• Product Name: (S)-N,N-dibenzyl-5-(5-methylpyrazin-2-yl)chroman-3-amine
• Synonyms: (S)-N,N-dibenzyl-5-(5-methylpyrazin-2-yl)chroman-3-amine
• CAS NO: 1395896-87-3
• Molecular Weight: 421.542
• Mol File: 1395896-87-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-N,N-dibenzyl-5-(5-methylpyrazin-2-yl)chroman-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N,N-dibenzyl-5-(5-methylpyrazin-2-yl)chroman-3-amine(1395896-87-3)
• EPA Substance Registry System: (S)-N,N-dibenzyl-5-(5-methylpyrazin-2-yl)chroman-3-amine(1395896-87-3)

Safety Data

• Hazardous Substances Data: 1395896-87-3(Hazardous Substances Data)

Upstream product

• 1072854-74-0 (S)-N,N-dibenzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chroman-3-amine 
• 98006-90-7 2-bromo-5-methyl-pyrazine 
• 1072854-55-7 (3S)-3-(dibenzylamino)-3,4-dihydro-2H-chromen-5-yl trifluoromethanesulfonate 
• 1309981-12-1 C₅H₇BN₂O₂ 
• 221359-96-2 C₂₄H₂₅NO₂ 
• 100-39-0 benzyl bromide 
• 117422-50-1 (3S)-3-amino-5-methoxy-3,4-dihydro-2H-1-benzopyran 

Relevant articles and documents

Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers

Recent findings showing a relation between mutations in the Na V1.7 channel in humans and altered pain sensation has contributed to increase the attractiveness of this ion channel as target for development of potential analgesics. Amido chromanes 1 and 2 were identified as blockers of the NaV1.7 channel and analogues with modifications of the 5-substituent and the carboxamide part of the molecule were prepared to establish the structure-activity relationship. Compounds 13 and 29 with good overall in vitro and in vivo rat PK profile were identified. Furthermore, 29 showed in vivo efficacy in a nociceptive pain model.