1396744-24-3

Basic information

• Product Name: C₂₀H₂₂N₄O₅S
• Synonyms: C₂₀H₂₂N₄O₅S
• CAS NO: 1396744-24-3
• Molecular Weight: 430.484
• Mol File: 1396744-24-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₂N₄O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₂N₄O₅S(1396744-24-3)
• EPA Substance Registry System: C₂₀H₂₂N₄O₅S(1396744-24-3)

Safety Data

• Hazardous Substances Data: 1396744-24-3(Hazardous Substances Data)

Upstream product

• 88612-61-7 ethyl 6-methoxyindole-3-carboxylate 
• 90924-43-9 6-methoxy-1H-indole-3-carboxylic acid 
• 90840-48-5 6-methoxyindole-3-carbohydrazide 
• 35967-24-9 (3,4,5-trimethoxyphenyl)isothiocyanate 

Downstream Products

• 1396743-90-0 C₂₀H₂₀N₄O₄S 

Relevant articles and documents

A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles as potent cytotoxic agents

A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles 6a-v were prepared and studied for their anticancer activity against selected human cancer cell lines. The reaction of indolylhydrazides 3a-h with a variety of aryl isothiocyanates 4 afforded the key intermediate thiosemicarbazides 5a-v, which upon treatment with acetyl chloride produced the 2-arylamino-5-(indolyl)-1,3,4- thiadiazoles 6a-v in good yields. Most of the synthesized compounds showed selective cytotoxicity towards human breast cancer cell line (MDA-MB-231). Of the synthesized 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles, compound 6f is the most potent towards tested cancer cell lines (IC50 = 0.15-1.18 μM).