88612-61-7

Upstream product

• 1033265-39-2 ethyl 2-(4-methoxy-2-nitrophenyl)propenoate 
• 64-17-5 ethanol 
• 90924-43-9 6-methoxy-1H-indole-3-carboxylic acid 

Downstream Products

• 1396744-22-1 C₁₈H₁₈N₄O₃S 
• 1396744-24-3 C₂₀H₂₂N₄O₅S 
• 1396743-88-6 C₁₈H₁₆N₄O₂S 
• 1396743-90-0 C₂₀H₂₀N₄O₄S 

Relevant academic research and scientific papers

A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles as potent cytotoxic agents

A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles 6a-v were prepared and studied for their anticancer activity against selected human cancer cell lines. The reaction of indolylhydrazides 3a-h with a variety of aryl isothiocyanates 4 afforded the key intermediate thiosemicarbazides 5a-v, which upon treatment with acetyl chloride produced the 2-arylamino-5-(indolyl)-1,3,4- thiadiazoles 6a-v in good yields. Most of the synthesized compounds showed selective cytotoxicity towards human breast cancer cell line (MDA-MB-231). Of the synthesized 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles, compound 6f is the most potent towards tested cancer cell lines (IC50 = 0.15-1.18 μM).

Palladium-catalyzed synthesis of 3-indolecarboxylic acid derivatives

Indoles having an ester functionality in the 3-position were prepared from 2-(2-nitrophenyl)propenoic acid derivatives via a palladium-catalyzed reductive N-heteroannulation using carbon monoxide as the ultimate reducing agent. The starting materials were