139676-51-0

Basic information

• Product Name: Methanone, [1-(2-hydroxyethyl)-4-piperidinyl]phenyl-
• Synonyms: [1-(2-Hydroxy-ethyl)-piperidin-4-yl]-phenyl-methanone
• CAS NO: 139676-51-0
• Molecular Formula: C14H19NO2
• Molecular Weight: 233.30600
• Mol File: 139676-51-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 382.6±32.0 °C(Predicted)
• Density: 1.113±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Methanone, [1-(2-hydroxyethyl)-4-piperidinyl]phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [1-(2-hydroxyethyl)-4-piperidinyl]phenyl-(139676-51-0)
• EPA Substance Registry System: Methanone, [1-(2-hydroxyethyl)-4-piperidinyl]phenyl-(139676-51-0)

Safety Data

• Hazardous Substances Data: 139676-51-0(Hazardous Substances Data)

Upstream product

• 624-76-0 Iodoethanol 
• 37586-22-4 4-benzoylpiperidine 
• 540-51-2 2-bromoethanol 

Downstream Products

• 195507-51-8 (1-(2-chloroethyl)piperidin-4-yl)(phenyl)methanone 

Relevant articles and documents

Convenient new synthesis of umeclidinium bromide

Umeclidinium bromide, a drug used for chronic obstructive pulmonary disease, is synthesized through a new intermediate of phenyl(quinuclidin-4-yl)methanone. This novel method with simple operation flow and cheap reagents, makes it suitable for scale up. The overall four-step process provides umeclidinium bromide in 29% yield and the purity up to 99.83%. The X-ray crystal structure of the drug molecule was first reported.